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Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU
BACKGROUND/AIM: Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy wi...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific and Technological Research Council of Turkey
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203135/ https://www.ncbi.nlm.nih.gov/pubmed/32718127 http://dx.doi.org/10.3906/sag-2006-173 |
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author | ÇALIK BAŞARAN, Nursel UYAROĞLU, Oğuz Abdullah TELLİ DİZMAN, Gülçin ÖZIŞIK, Lale ŞAHİN, Taha Koray TAŞ, Zahit İNKAYA, Ahmet Çağkan KARAHAN, Sevilay ALP, Şehnaz ALP, Alpaslan METAN, Gökhan ZARAKOLU, Pınar SAİN GÜVEN, Gülay ÖZ, Şerife Gül TOPELİ, Arzu UZUN, Ömrüm AKOVA, Murat ÜNAL, Serhat |
author_facet | ÇALIK BAŞARAN, Nursel UYAROĞLU, Oğuz Abdullah TELLİ DİZMAN, Gülçin ÖZIŞIK, Lale ŞAHİN, Taha Koray TAŞ, Zahit İNKAYA, Ahmet Çağkan KARAHAN, Sevilay ALP, Şehnaz ALP, Alpaslan METAN, Gökhan ZARAKOLU, Pınar SAİN GÜVEN, Gülay ÖZ, Şerife Gül TOPELİ, Arzu UZUN, Ömrüm AKOVA, Murat ÜNAL, Serhat |
author_sort | ÇALIK BAŞARAN, Nursel |
collection | PubMed |
description | BACKGROUND/AIM: Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital. MATERIALS AND METHODS: This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected. RESULTS: We included 174 consecutive probable/confirmed COVID-19 adult patients hospitalized in the Internal Medicine wards of the University Adult Hospital between March 20 and April 30, 2020. The median age was 45.5 (19–92) years and 91 patients (52.3%) were male. One hundred and twenty (69%) were confirmed microbiologically, 41 (23.5%) were radiologically diagnosed, and 13 (7.5%) were clinically suspected (negative microbiological and radiological findings compatible with COVID-19); 35 (20.1%) had mild, 107 (61.5%) moderate disease, and 32 (18.4%) had severe pneumonia. Out of 171 cases, 130 (74.3%) showed pneumonia; 80 were typical, and 50 showed indeterminate infiltration for COVID-19. Patients were admitted within a median of 3 days (0-14 days) after symptoms appear. The median duration of hospitalization was 4 days (0-28 days). In this case series, 13.2% patients were treated with hydroxychloroquine alone, 64.9% with hydroxychloroquine plus azithromycin, and 18.4% with regimens including favipiravir. A total of 15 patients (8.5%) were transferred to the ICU. Four patients died (2.2%). CONCLUSION: In our series, 174 patients were admitted to the hospital wards for COVID-19, 69% were confirmed with PCR and/or antibody test. At the time of admission, nearly one fifth of the patients had severe diseases. Of the patients, 95.4% received hydroxychloroquine alone or in combination. The overall case fatality rate was 2.2%. |
format | Online Article Text |
id | pubmed-8203135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-82031352021-06-24 Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU ÇALIK BAŞARAN, Nursel UYAROĞLU, Oğuz Abdullah TELLİ DİZMAN, Gülçin ÖZIŞIK, Lale ŞAHİN, Taha Koray TAŞ, Zahit İNKAYA, Ahmet Çağkan KARAHAN, Sevilay ALP, Şehnaz ALP, Alpaslan METAN, Gökhan ZARAKOLU, Pınar SAİN GÜVEN, Gülay ÖZ, Şerife Gül TOPELİ, Arzu UZUN, Ömrüm AKOVA, Murat ÜNAL, Serhat Turk J Med Sci Article BACKGROUND/AIM: Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital. MATERIALS AND METHODS: This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected. RESULTS: We included 174 consecutive probable/confirmed COVID-19 adult patients hospitalized in the Internal Medicine wards of the University Adult Hospital between March 20 and April 30, 2020. The median age was 45.5 (19–92) years and 91 patients (52.3%) were male. One hundred and twenty (69%) were confirmed microbiologically, 41 (23.5%) were radiologically diagnosed, and 13 (7.5%) were clinically suspected (negative microbiological and radiological findings compatible with COVID-19); 35 (20.1%) had mild, 107 (61.5%) moderate disease, and 32 (18.4%) had severe pneumonia. Out of 171 cases, 130 (74.3%) showed pneumonia; 80 were typical, and 50 showed indeterminate infiltration for COVID-19. Patients were admitted within a median of 3 days (0-14 days) after symptoms appear. The median duration of hospitalization was 4 days (0-28 days). In this case series, 13.2% patients were treated with hydroxychloroquine alone, 64.9% with hydroxychloroquine plus azithromycin, and 18.4% with regimens including favipiravir. A total of 15 patients (8.5%) were transferred to the ICU. Four patients died (2.2%). CONCLUSION: In our series, 174 patients were admitted to the hospital wards for COVID-19, 69% were confirmed with PCR and/or antibody test. At the time of admission, nearly one fifth of the patients had severe diseases. Of the patients, 95.4% received hydroxychloroquine alone or in combination. The overall case fatality rate was 2.2%. The Scientific and Technological Research Council of Turkey 2021-04-30 /pmc/articles/PMC8203135/ /pubmed/32718127 http://dx.doi.org/10.3906/sag-2006-173 Text en Copyright © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article ÇALIK BAŞARAN, Nursel UYAROĞLU, Oğuz Abdullah TELLİ DİZMAN, Gülçin ÖZIŞIK, Lale ŞAHİN, Taha Koray TAŞ, Zahit İNKAYA, Ahmet Çağkan KARAHAN, Sevilay ALP, Şehnaz ALP, Alpaslan METAN, Gökhan ZARAKOLU, Pınar SAİN GÜVEN, Gülay ÖZ, Şerife Gül TOPELİ, Arzu UZUN, Ömrüm AKOVA, Murat ÜNAL, Serhat Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU |
title | Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU |
title_full | Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU |
title_fullStr | Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU |
title_full_unstemmed | Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU |
title_short | Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU |
title_sort | outcome of noncritical covid-19 patients with early hospitalization and early antiviral treatment outside the icu |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203135/ https://www.ncbi.nlm.nih.gov/pubmed/32718127 http://dx.doi.org/10.3906/sag-2006-173 |
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