Active Tumoral/Tumor Environmental Dual-Targeting by Non-Covalently Arming with Trispecific Antibodies or Dual-Bispecific Antibodies on Docetaxel-Loaded mPEGylated Nanocarriers to Enhance Chemotherapeutic Efficacy and Minimize Systemic Toxicity

PURPOSE: This study was aimed at developing the trispecific antibodies (anti-EGFR/anti-FAP/anti-mPEG, TsAb) or dual bispecific antibodies (anti-EGFR/anti-mPEG and anti-FAP/anti-mPEG) docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micelles (mPEG-lsbPMs) for improving the targeting efficiency a...

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Detalles Bibliográficos
Autores principales: Cheng, Wei-Jie, Lin, Shyr-Yi, Chen, Michael, Chen, Ling-Chun, Ho, Hsiu-O, Chuang, Kuo-Hsiang, Sheu, Ming-Thau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203191/
https://www.ncbi.nlm.nih.gov/pubmed/34140769
http://dx.doi.org/10.2147/IJN.S301237

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