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Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice

BACKGROUND: The serine/threonine protein phosphatase, PP2A, is thought to play a central role in the molecular pathogenesis of Alzheimer’s disease (AD), and the activity and substrate specificity of PP2A is regulated, in part, through methylation and demethylation of its catalytic subunit. Previousl...

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Detalles Bibliográficos
Autores principales:	Gnanaprakash, Madhumathi, Staniszewski, Agnieszka, Zhang, Hong, Pitstick, Rose, Kavanaugh, Michael P., Arancio, Ottavio, Nicholls, Russell E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203222/ https://www.ncbi.nlm.nih.gov/pubmed/33459709 http://dx.doi.org/10.3233/JAD-200462

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