Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment

We demonstrated the benefit of the probiotic strain, Bifidobacterium breve MCC1274 (synonym B. breve A1), at improving cognition in our previous double-blind, placebo-controlled clinical study. Analysis of the association of blood parameters changes with the improvement of cognitive function reveale...

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Autores principales: Bernier, Francois, Ohno, Kazuya, Katsumata, Noriko, Shimizu, Takashi, Xiao, Jinzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203240/
https://www.ncbi.nlm.nih.gov/pubmed/33814441
http://dx.doi.org/10.3233/JAD-201488
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author Bernier, Francois
Ohno, Kazuya
Katsumata, Noriko
Shimizu, Takashi
Xiao, Jinzhong
author_facet Bernier, Francois
Ohno, Kazuya
Katsumata, Noriko
Shimizu, Takashi
Xiao, Jinzhong
author_sort Bernier, Francois
collection PubMed
description We demonstrated the benefit of the probiotic strain, Bifidobacterium breve MCC1274 (synonym B. breve A1), at improving cognition in our previous double-blind, placebo-controlled clinical study. Analysis of the association of blood parameters changes with the improvement of cognitive function revealed an inverse correlation of HbA1c with total RBANS score amelioration after the study only in the probiotic group (ρ= –0.4218, p = 0.0067). A stratified analysis based on baseline HbA1c with a median value showed a more remarkable benefit by the probiotic supplementation in the higher median subgroup. These data support the mechanism of anti-inflammation in improving cognition by the probiotic strain.
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spelling pubmed-82032402021-06-28 Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment Bernier, Francois Ohno, Kazuya Katsumata, Noriko Shimizu, Takashi Xiao, Jinzhong J Alzheimers Dis Short Communication We demonstrated the benefit of the probiotic strain, Bifidobacterium breve MCC1274 (synonym B. breve A1), at improving cognition in our previous double-blind, placebo-controlled clinical study. Analysis of the association of blood parameters changes with the improvement of cognitive function revealed an inverse correlation of HbA1c with total RBANS score amelioration after the study only in the probiotic group (ρ= –0.4218, p = 0.0067). A stratified analysis based on baseline HbA1c with a median value showed a more remarkable benefit by the probiotic supplementation in the higher median subgroup. These data support the mechanism of anti-inflammation in improving cognition by the probiotic strain. IOS Press 2021-05-18 /pmc/articles/PMC8203240/ /pubmed/33814441 http://dx.doi.org/10.3233/JAD-201488 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Bernier, Francois
Ohno, Kazuya
Katsumata, Noriko
Shimizu, Takashi
Xiao, Jinzhong
Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment
title Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment
title_full Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment
title_fullStr Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment
title_full_unstemmed Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment
title_short Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment
title_sort association of plasma hemoglobin a1c with improvement of cognitive functions by probiotic bifidobacterium breve supplementation in healthy adults with mild cognitive impairment
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203240/
https://www.ncbi.nlm.nih.gov/pubmed/33814441
http://dx.doi.org/10.3233/JAD-201488
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