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Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms
PURPOSE: Using psychobiotics to modify the gut microbiome has been shown to improve the anxiety and depression situation of patients with chronic gastrointestinal (GI) symptoms. This study evaluated changes in depression, anxiety, GI symptomss and side effects when patients used a multispecies probi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203266/ https://www.ncbi.nlm.nih.gov/pubmed/34140777 http://dx.doi.org/10.2147/JMDH.S312316 |
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author | Dao, Viet Hang Hoang, Long Bao Trinh, Thi Oanh Tran, Thi Thu Trang Dao, Van Long |
author_facet | Dao, Viet Hang Hoang, Long Bao Trinh, Thi Oanh Tran, Thi Thu Trang Dao, Van Long |
author_sort | Dao, Viet Hang |
collection | PubMed |
description | PURPOSE: Using psychobiotics to modify the gut microbiome has been shown to improve the anxiety and depression situation of patients with chronic gastrointestinal (GI) symptoms. This study evaluated changes in depression, anxiety, GI symptomss and side effects when patients used a multispecies probiotics product. PATIENTS AND METHODS: A single-center uncontrolled trial was conducted in patients with chronic GI symptoms, anxiety and depression who used a multispecies probiotics product. The patients were screened for anxiety and depression symptoms using the Hospital Anxiety and Depression Scale (HADS). Those who had a component score of 8 or higher were given the multispecies probiotics product for 2 months and followed up after 1 and 2 months. All data are collected and managed in a case report form. RESULTS: Eighty-three patients were enrolled, with a mean age (SD) of 43.9 (12.3) years; 73.5% of the patients were female. Of these patients, 8 met the Rome IV criteria for irritable bowel syndrome. The HADS scores displayed significant improvement at follow-up. The mean (SD) total HADS scores were 20.0 (6.3), 7.2 (5.4), and 4.9 (5.1) at baseline, 1 month, and 2 months, respectively. Quality of life also improved significantly. A small proportion (<5%) of patients developed mild symptoms, including fullness, diarrhea, and sleep complaints. CONCLUSION: After 2 months using the probiotic product, the symptoms of anxiety and depression improved significantly. Mild gastrointestinal or constitutional symptoms developed in some patients. |
format | Online Article Text |
id | pubmed-8203266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-82032662021-06-16 Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms Dao, Viet Hang Hoang, Long Bao Trinh, Thi Oanh Tran, Thi Thu Trang Dao, Van Long J Multidiscip Healthc Original Research PURPOSE: Using psychobiotics to modify the gut microbiome has been shown to improve the anxiety and depression situation of patients with chronic gastrointestinal (GI) symptoms. This study evaluated changes in depression, anxiety, GI symptomss and side effects when patients used a multispecies probiotics product. PATIENTS AND METHODS: A single-center uncontrolled trial was conducted in patients with chronic GI symptoms, anxiety and depression who used a multispecies probiotics product. The patients were screened for anxiety and depression symptoms using the Hospital Anxiety and Depression Scale (HADS). Those who had a component score of 8 or higher were given the multispecies probiotics product for 2 months and followed up after 1 and 2 months. All data are collected and managed in a case report form. RESULTS: Eighty-three patients were enrolled, with a mean age (SD) of 43.9 (12.3) years; 73.5% of the patients were female. Of these patients, 8 met the Rome IV criteria for irritable bowel syndrome. The HADS scores displayed significant improvement at follow-up. The mean (SD) total HADS scores were 20.0 (6.3), 7.2 (5.4), and 4.9 (5.1) at baseline, 1 month, and 2 months, respectively. Quality of life also improved significantly. A small proportion (<5%) of patients developed mild symptoms, including fullness, diarrhea, and sleep complaints. CONCLUSION: After 2 months using the probiotic product, the symptoms of anxiety and depression improved significantly. Mild gastrointestinal or constitutional symptoms developed in some patients. Dove 2021-06-10 /pmc/articles/PMC8203266/ /pubmed/34140777 http://dx.doi.org/10.2147/JMDH.S312316 Text en © 2021 Dao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Dao, Viet Hang Hoang, Long Bao Trinh, Thi Oanh Tran, Thi Thu Trang Dao, Van Long Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms |
title | Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms |
title_full | Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms |
title_fullStr | Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms |
title_full_unstemmed | Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms |
title_short | Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms |
title_sort | psychobiotics for patients with chronic gastrointestinal disorders having anxiety or depression symptoms |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203266/ https://www.ncbi.nlm.nih.gov/pubmed/34140777 http://dx.doi.org/10.2147/JMDH.S312316 |
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