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In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains

BACKGROUND: Mutations in PRESENILIN 2 (PSEN2) cause early onset familial Alzheimer’s disease (EOfAD) but their mode of action remains elusive. One consistent observation for all PRESENILIN gene mutations causing EOfAD is that a transcript is produced with a reading frame terminated by the normal sto...

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Detalles Bibliográficos
Autores principales:	Barthelson, Karissa, Pederson, Stephen Martin, Newman, Morgan, Jiang, Haowei, Lardelli, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203281/ https://www.ncbi.nlm.nih.gov/pubmed/34189411 http://dx.doi.org/10.3233/ADR-200279

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