Cargando…

Potential Virus Involvement in Alzheimer’s Disease: Results from a Phase IIa Trial Evaluating Apovir, an Antiviral Drug Combination

BACKGROUND: Accumulating data suggest infectious agents are involved in Alzheimer’s disease (AD). The two primary aims of this trial were to assess safety and efficacy of an antiviral drug combination on AD progression. OBJECTIVE: The trial evaluated whether Apovir, a combination of two antiviral ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lindblom, Nina, Lindquist, Lars, Westman, Jacob, Åström, Mikael, Bullock, Roger, Hendrix, Suzanne, Wahlund, Lars-Olof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203284/ https://www.ncbi.nlm.nih.gov/pubmed/34189413 http://dx.doi.org/10.3233/ADR-210301

Ejemplares similares

The heterogeneity within Alzheimer's disease
por: Ferreira, Daniel, et al.
Publicado: (2018)

Is the subcallosal medial prefrontal cortex a common site of atrophy in Alzheimer's disease and frontotemporal lobar degeneration?
por: Lindberg, Olof, et al.
Publicado: (2012)

Meta-Review of CSF Core Biomarkers in Alzheimer’s Disease: The State-of-the-Art after the New Revised Diagnostic Criteria
por: Ferreira, Daniel, et al.
Publicado: (2014)

Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease
por: Voevodskaya, Olga, et al.
Publicado: (2016)

The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease
por: Voevodskaya, Olga, et al.
Publicado: (2014)

(Dis‐)Connected Dots in Dementia with Lewy Bodies—A Systematic Review of Connectivity Studies
por: Habich, Annegret, et al.
Publicado: (2022)

Improving CSF Biomarkers’ Performance for Predicting Progression from Mild Cognitive Impairment to Alzheimer’s Disease by Considering Different Confounding Factors: A Meta-Analysis
por: Ferreira, Daniel, et al.
Publicado: (2014)

Diverging Progression of Network Disruption and Atrophy in Alzheimer’s Disease and Semantic Dementia
por: Andreotti, Jennifer, et al.
Publicado: (2016)

Atrophy of the Posterior Subiculum Is Associated with Memory Impairment, Tau- and Aβ Pathology in Non-demented Individuals
por: Lindberg, Olof, et al.
Publicado: (2017)

In vivo (1)H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
por: Westman, Eric, et al.
Publicado: (2009)

Reproducible segmentation of white matter hyperintensities using a new statistical definition
por: Damangir, Soheil, et al.
Publicado: (2016)

Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
por: Huang, Chaorui, et al.
Publicado: (2002)

The cholinergic system in subtypes of Alzheimer’s disease: an in vivo longitudinal MRI study
por: Machado, Alejandra, et al.
Publicado: (2020)

The Effect of Age Correction on Multivariate Classification in Alzheimer’s Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects
por: Falahati, Farshad, et al.
Publicado: (2015)

Ratio of Aβ42/P-tau(181p) in CSF is associated with aberrant default mode network in AD
por: Li, Xiaozhen, et al.
Publicado: (2013)

Default Mode Network Complexity and Cognitive Decline in Mild Alzheimer’s Disease
por: Grieder, Matthias, et al.
Publicado: (2018)

Cerebral inflammation is an underlying mechanism of early death in Alzheimer’s disease: a 13-year cause-specific multivariate mortality study
por: Nägga, Katarina, et al.
Publicado: (2014)

Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease
por: Poulakis, Konstantinos, et al.
Publicado: (2022)

Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications
por: Ferreira, Daniel, et al.
Publicado: (2017)

Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort
por: Aguilar, Carlos, et al.
Publicado: (2014)

Monitoring disease progression in mild cognitive impairment: Associations between atrophy patterns, cognition, APOE and amyloid
por: Falahati, Farshad, et al.
Publicado: (2017)

AVRA: Automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks
por: Mårtensson, Gustav, et al.
Publicado: (2019)

Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
por: Wallert, John, et al.
Publicado: (2021)

Sensitivity and Specificity of Medial Temporal Lobe Visual Ratings and Multivariate Regional MRI Classification in Alzheimer's Disease
por: Westman, Eric, et al.
Publicado: (2011)

Imaging biomarkers of dementia: recommended visual rating scales with teaching cases
por: Wahlund, Lars-Olof, et al.
Publicado: (2016)

The Use of Magnetic Resonance Imaging Techniques in Assessing the Effects of Alcohol Consumption and Heavy Drinking on the Adolescent Brain: A Scoping Review Protocol
por: Hornsby, Nancy, et al.
Publicado: (2021)

Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease
por: Pereira, Joana B., et al.
Publicado: (2016)

Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer’s Disease in Two Independent Cohorts
por: Khan, Wasim, et al.
Publicado: (2014)

Plasma Biomarkers of Brain Atrophy in Alzheimer's Disease
por: Thambisetty, Madhav, et al.
Publicado: (2011)

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease
por: Boccardi, Virginia, et al.
Publicado: (2019)

Education increases reserve against Alzheimer’s disease—evidence from structural MRI analysis
por: Liu, Yawu, et al.
Publicado: (2012)

The MemClin project: a prospective multi memory clinics study targeting early stages of cognitive impairment
por: Ekman, Urban, et al.
Publicado: (2020)

Functional Connectivity Alterations of the Temporal Lobe and Hippocampus in Semantic Dementia and Alzheimer’s Disease
por: Schwab, Simon, et al.
Publicado: (2020)

Brain myoinositol as a potential marker of amyloid-related pathology: A longitudinal study
por: Voevodskaya, Olga, et al.
Publicado: (2019)

The Association Between Temporal Atrophy and Episodic Memory Is Moderated by Education in a Multi-Center Memory Clinic Sample
por: Gyllenhammar, Måns, et al.
Publicado: (2023)

Blood Concentrations of Homocysteine and Methylmalonic Acid among Demented and Non-Demented Swedish Elderly with and without Home Care Services and Vitamin B(12) Prescriptions
por: Hagnelius, Nils-Olof, et al.
Publicado: (2012)

Functional connectivity in behavioral variant frontotemporal dementia
por: Ferreira, Luiz Kobuti, et al.
Publicado: (2022)

Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities
por: Cedres, Nira, et al.
Publicado: (2020)

Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals
por: Cedres, Nira, et al.
Publicado: (2022)

MRI Markers of Small Vessel Disease and the APOE Allele in Cognitive Impairment
por: Shams, Mana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_b77id0b1jgq6rdvhm7mpurqisf