Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing five preclinical mouse tumor models with heterogeneous tumor microenvironments, we aimed to relate the rate of tum...

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Detalles Bibliográficos
Autores principales: Nicolas-Boluda, Alba, Vaquero, Javier, Vimeux, Lene, Guilbert, Thomas, Barrin, Sarah, Kantari-Mimoun, Chahrazade, Ponzo, Matteo, Renault, Gilles, Deptula, Piotr, Pogoda, Katarzyna, Bucki, Robert, Cascone, Ilaria, Courty, José, Fouassier, Laura, Gazeau, Florence, Donnadieu, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203293/
https://www.ncbi.nlm.nih.gov/pubmed/34106045
http://dx.doi.org/10.7554/eLife.58688

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