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miR-181a-regulated pathways in T-cell differentiation and aging

MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells, with miR-181a regulating T cell activation thresholds during thymic T cell development and...

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Autores principales: Kim, Chulwoo, Ye, Zhongde, Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203492/
https://www.ncbi.nlm.nih.gov/pubmed/34130717
http://dx.doi.org/10.1186/s12979-021-00240-1
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author Kim, Chulwoo
Ye, Zhongde
Weyand, Cornelia M.
Goronzy, Jörg J.
author_facet Kim, Chulwoo
Ye, Zhongde
Weyand, Cornelia M.
Goronzy, Jörg J.
author_sort Kim, Chulwoo
collection PubMed
description MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells, with miR-181a regulating T cell activation thresholds during thymic T cell development and during activation of peripheral T cells. Intriguingly, miR-181a is implicated in defective antiviral and vaccine responses in older individuals, as its expression declines in naïve T cells with increasing age. Here, we review the pathways that are regulated by miR-181a and that explain the unique role of miR-181a in T cell development, T cell activation and antiviral T cell responses. These studies provide a framework for understanding how a decline in miR-181a expression in T cells could contribute to age-related defects in adaptive immunity. We furthermore review the mechanisms that cause the age-related decline in miR-181a expression and discuss the potential of restoring miR-181a expression or targeting miR-181a-regulated pathways to improve impaired T cell responses in older individuals.
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spelling pubmed-82034922021-06-15 miR-181a-regulated pathways in T-cell differentiation and aging Kim, Chulwoo Ye, Zhongde Weyand, Cornelia M. Goronzy, Jörg J. Immun Ageing Review MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells, with miR-181a regulating T cell activation thresholds during thymic T cell development and during activation of peripheral T cells. Intriguingly, miR-181a is implicated in defective antiviral and vaccine responses in older individuals, as its expression declines in naïve T cells with increasing age. Here, we review the pathways that are regulated by miR-181a and that explain the unique role of miR-181a in T cell development, T cell activation and antiviral T cell responses. These studies provide a framework for understanding how a decline in miR-181a expression in T cells could contribute to age-related defects in adaptive immunity. We furthermore review the mechanisms that cause the age-related decline in miR-181a expression and discuss the potential of restoring miR-181a expression or targeting miR-181a-regulated pathways to improve impaired T cell responses in older individuals. BioMed Central 2021-06-15 /pmc/articles/PMC8203492/ /pubmed/34130717 http://dx.doi.org/10.1186/s12979-021-00240-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kim, Chulwoo
Ye, Zhongde
Weyand, Cornelia M.
Goronzy, Jörg J.
miR-181a-regulated pathways in T-cell differentiation and aging
title miR-181a-regulated pathways in T-cell differentiation and aging
title_full miR-181a-regulated pathways in T-cell differentiation and aging
title_fullStr miR-181a-regulated pathways in T-cell differentiation and aging
title_full_unstemmed miR-181a-regulated pathways in T-cell differentiation and aging
title_short miR-181a-regulated pathways in T-cell differentiation and aging
title_sort mir-181a-regulated pathways in t-cell differentiation and aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203492/
https://www.ncbi.nlm.nih.gov/pubmed/34130717
http://dx.doi.org/10.1186/s12979-021-00240-1
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