Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics

The central amygdala (CE) emerges as a critical node for affective processing. However, how CE local circuitry interacts with brain wide affective states is yet uncharted. Using basic nociception as proxy, we find that gene expression suggests diverging roles of the two major CE neuronal populations...

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Autores principales: Wank, Isabel, Pliota, Pinelopi, Badurek, Sylvia, Kraitsy, Klaus, Kaczanowska, Joanna, Griessner, Johannes, Kreitz, Silke, Hess, Andreas, Haubensak, Wulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203648/
https://www.ncbi.nlm.nih.gov/pubmed/34127787
http://dx.doi.org/10.1038/s42003-021-02262-3
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author Wank, Isabel
Pliota, Pinelopi
Badurek, Sylvia
Kraitsy, Klaus
Kaczanowska, Joanna
Griessner, Johannes
Kreitz, Silke
Hess, Andreas
Haubensak, Wulf
author_facet Wank, Isabel
Pliota, Pinelopi
Badurek, Sylvia
Kraitsy, Klaus
Kaczanowska, Joanna
Griessner, Johannes
Kreitz, Silke
Hess, Andreas
Haubensak, Wulf
author_sort Wank, Isabel
collection PubMed
description The central amygdala (CE) emerges as a critical node for affective processing. However, how CE local circuitry interacts with brain wide affective states is yet uncharted. Using basic nociception as proxy, we find that gene expression suggests diverging roles of the two major CE neuronal populations, protein kinase C δ-expressing (PKCδ(+)) and somatostatin-expressing (SST(+)) cells. Optogenetic (o)fMRI demonstrates that PKCδ(+)/SST(+) circuits engage specific separable functional subnetworks to modulate global brain dynamics by a differential bottom-up vs. top-down hierarchical mesoscale mechanism. This diverging modulation impacts on nocifensive behavior and may underly CE control of affective processing.
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spelling pubmed-82036482021-07-01 Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics Wank, Isabel Pliota, Pinelopi Badurek, Sylvia Kraitsy, Klaus Kaczanowska, Joanna Griessner, Johannes Kreitz, Silke Hess, Andreas Haubensak, Wulf Commun Biol Article The central amygdala (CE) emerges as a critical node for affective processing. However, how CE local circuitry interacts with brain wide affective states is yet uncharted. Using basic nociception as proxy, we find that gene expression suggests diverging roles of the two major CE neuronal populations, protein kinase C δ-expressing (PKCδ(+)) and somatostatin-expressing (SST(+)) cells. Optogenetic (o)fMRI demonstrates that PKCδ(+)/SST(+) circuits engage specific separable functional subnetworks to modulate global brain dynamics by a differential bottom-up vs. top-down hierarchical mesoscale mechanism. This diverging modulation impacts on nocifensive behavior and may underly CE control of affective processing. Nature Publishing Group UK 2021-06-14 /pmc/articles/PMC8203648/ /pubmed/34127787 http://dx.doi.org/10.1038/s42003-021-02262-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wank, Isabel
Pliota, Pinelopi
Badurek, Sylvia
Kraitsy, Klaus
Kaczanowska, Joanna
Griessner, Johannes
Kreitz, Silke
Hess, Andreas
Haubensak, Wulf
Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics
title Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics
title_full Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics
title_fullStr Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics
title_full_unstemmed Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics
title_short Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics
title_sort central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203648/
https://www.ncbi.nlm.nih.gov/pubmed/34127787
http://dx.doi.org/10.1038/s42003-021-02262-3
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