Effects of curcumin on the bioavailability of dioxin-like pollutants in rats

The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the hi...

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Autores principales: Cai, Delei, Chen, Qing, Han, Jianlong, Song, Yanhua, Meng, Zhen, Zheng, Yibin, Shen, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203761/
https://www.ncbi.nlm.nih.gov/pubmed/34127775
http://dx.doi.org/10.1038/s41598-021-92085-3
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author Cai, Delei
Chen, Qing
Han, Jianlong
Song, Yanhua
Meng, Zhen
Zheng, Yibin
Shen, Haitao
author_facet Cai, Delei
Chen, Qing
Han, Jianlong
Song, Yanhua
Meng, Zhen
Zheng, Yibin
Shen, Haitao
author_sort Cai, Delei
collection PubMed
description The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Moreover, curcumin lowered the TEQ of DL-PCBs in the liver of male rats, but not female rats. The significant decrease in the bioavailability of PCDD/Fs and DL-PCBs demonstrates the potential detoxification mechanisms of curcumin.
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spelling pubmed-82037612021-06-16 Effects of curcumin on the bioavailability of dioxin-like pollutants in rats Cai, Delei Chen, Qing Han, Jianlong Song, Yanhua Meng, Zhen Zheng, Yibin Shen, Haitao Sci Rep Article The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Moreover, curcumin lowered the TEQ of DL-PCBs in the liver of male rats, but not female rats. The significant decrease in the bioavailability of PCDD/Fs and DL-PCBs demonstrates the potential detoxification mechanisms of curcumin. Nature Publishing Group UK 2021-06-14 /pmc/articles/PMC8203761/ /pubmed/34127775 http://dx.doi.org/10.1038/s41598-021-92085-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cai, Delei
Chen, Qing
Han, Jianlong
Song, Yanhua
Meng, Zhen
Zheng, Yibin
Shen, Haitao
Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_full Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_fullStr Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_full_unstemmed Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_short Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_sort effects of curcumin on the bioavailability of dioxin-like pollutants in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203761/
https://www.ncbi.nlm.nih.gov/pubmed/34127775
http://dx.doi.org/10.1038/s41598-021-92085-3
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