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Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy

The control of Covid 19 epidemics by public health policy in Italy during the first and the second epidemic waves has been driven by using reproductive number R(t)(t) to identify the supercritical (percolative), the subcritical (arrested), separated by the critical regime. Here we show that to quant...

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Autores principales: Campi, Gaetano, Mazziotti, Maria Vittoria, Valletta, Antonio, Ravagnan, Giampietro, Marcelli, Augusto, Perali, Andrea, Bianconi, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203777/
https://www.ncbi.nlm.nih.gov/pubmed/34127760
http://dx.doi.org/10.1038/s41598-021-91950-5
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author Campi, Gaetano
Mazziotti, Maria Vittoria
Valletta, Antonio
Ravagnan, Giampietro
Marcelli, Augusto
Perali, Andrea
Bianconi, Antonio
author_facet Campi, Gaetano
Mazziotti, Maria Vittoria
Valletta, Antonio
Ravagnan, Giampietro
Marcelli, Augusto
Perali, Andrea
Bianconi, Antonio
author_sort Campi, Gaetano
collection PubMed
description The control of Covid 19 epidemics by public health policy in Italy during the first and the second epidemic waves has been driven by using reproductive number R(t)(t) to identify the supercritical (percolative), the subcritical (arrested), separated by the critical regime. Here we show that to quantify the Covid-19 spreading rate with containment measures there is a need of a 3D expanded parameter space phase diagram built by the combination of R(t)(t) and doubling time T(d)(t). In this space we identify the Covid-19 dynamics in Italy and its administrative Regions. The supercritical regime is mathematically characterized by (i) the power law of T(d) vs. [R(t)(t) − 1] and (ii) the exponential behaviour of T(d) vs. time, either in the first and in the second wave. The novel 3D phase diagram shows clearly metastable states appearing before and after the second wave critical regime. for loosening quarantine and tracing of actives cases. The metastable states are precursors of the abrupt onset of a next nascent wave supercritical regime. This dynamic description allows epidemics predictions needed by policymakers interested to point to the target "zero infections" with the elimination of SARS-CoV-2, using the Finding mobile Tracing policy joint with vaccination-campaign, in order to avoid the emergence of recurrent new variants of SARS-CoV-2 virus, accompined by recurrent long lockdowns, with large economical losses, and large number of fatalities.
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spelling pubmed-82037772021-06-16 Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy Campi, Gaetano Mazziotti, Maria Vittoria Valletta, Antonio Ravagnan, Giampietro Marcelli, Augusto Perali, Andrea Bianconi, Antonio Sci Rep Article The control of Covid 19 epidemics by public health policy in Italy during the first and the second epidemic waves has been driven by using reproductive number R(t)(t) to identify the supercritical (percolative), the subcritical (arrested), separated by the critical regime. Here we show that to quantify the Covid-19 spreading rate with containment measures there is a need of a 3D expanded parameter space phase diagram built by the combination of R(t)(t) and doubling time T(d)(t). In this space we identify the Covid-19 dynamics in Italy and its administrative Regions. The supercritical regime is mathematically characterized by (i) the power law of T(d) vs. [R(t)(t) − 1] and (ii) the exponential behaviour of T(d) vs. time, either in the first and in the second wave. The novel 3D phase diagram shows clearly metastable states appearing before and after the second wave critical regime. for loosening quarantine and tracing of actives cases. The metastable states are precursors of the abrupt onset of a next nascent wave supercritical regime. This dynamic description allows epidemics predictions needed by policymakers interested to point to the target "zero infections" with the elimination of SARS-CoV-2, using the Finding mobile Tracing policy joint with vaccination-campaign, in order to avoid the emergence of recurrent new variants of SARS-CoV-2 virus, accompined by recurrent long lockdowns, with large economical losses, and large number of fatalities. Nature Publishing Group UK 2021-06-14 /pmc/articles/PMC8203777/ /pubmed/34127760 http://dx.doi.org/10.1038/s41598-021-91950-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Campi, Gaetano
Mazziotti, Maria Vittoria
Valletta, Antonio
Ravagnan, Giampietro
Marcelli, Augusto
Perali, Andrea
Bianconi, Antonio
Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy
title Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy
title_full Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy
title_fullStr Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy
title_full_unstemmed Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy
title_short Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy
title_sort metastable states in plateaus and multi-wave epidemic dynamics of covid-19 spreading in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203777/
https://www.ncbi.nlm.nih.gov/pubmed/34127760
http://dx.doi.org/10.1038/s41598-021-91950-5
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