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Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor

The Phosphatase and tensin homolog (PTEN) gene is one of the most important tumor suppressor genes, which acts through its unique protein phosphatase and lipid phosphatase activity. PTEN protein is widely distributed and exhibits complex biological functions and regulatory modes. It is involved in t...

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Detalles Bibliográficos
Autores principales: He, Tianyu, Zhang, Xiaoyun, Hao, Jianyu, Ding, Shigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204087/
https://www.ncbi.nlm.nih.gov/pubmed/34140896
http://dx.doi.org/10.3389/fphys.2021.684529
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author He, Tianyu
Zhang, Xiaoyun
Hao, Jianyu
Ding, Shigang
author_facet He, Tianyu
Zhang, Xiaoyun
Hao, Jianyu
Ding, Shigang
author_sort He, Tianyu
collection PubMed
description The Phosphatase and tensin homolog (PTEN) gene is one of the most important tumor suppressor genes, which acts through its unique protein phosphatase and lipid phosphatase activity. PTEN protein is widely distributed and exhibits complex biological functions and regulatory modes. It is involved in the regulation of cell morphology, proliferation, differentiation, adhesion, and migration through a variety of signaling pathways. The role of PTEN in malignant tumors of the digestive system is well documented. Recent studies have indicated that PTEN may be closely related to many other benign processes in digestive organs. Emerging evidence suggests that PTEN is a potential therapeutic target in the context of several non-neoplastic diseases of the digestive tract. The recent discovery of PTEN isoforms is expected to help unravel more biological effects of PTEN in non-neoplastic digestive diseases.
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spelling pubmed-82040872021-06-16 Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor He, Tianyu Zhang, Xiaoyun Hao, Jianyu Ding, Shigang Front Physiol Physiology The Phosphatase and tensin homolog (PTEN) gene is one of the most important tumor suppressor genes, which acts through its unique protein phosphatase and lipid phosphatase activity. PTEN protein is widely distributed and exhibits complex biological functions and regulatory modes. It is involved in the regulation of cell morphology, proliferation, differentiation, adhesion, and migration through a variety of signaling pathways. The role of PTEN in malignant tumors of the digestive system is well documented. Recent studies have indicated that PTEN may be closely related to many other benign processes in digestive organs. Emerging evidence suggests that PTEN is a potential therapeutic target in the context of several non-neoplastic diseases of the digestive tract. The recent discovery of PTEN isoforms is expected to help unravel more biological effects of PTEN in non-neoplastic digestive diseases. Frontiers Media S.A. 2021-06-01 /pmc/articles/PMC8204087/ /pubmed/34140896 http://dx.doi.org/10.3389/fphys.2021.684529 Text en Copyright © 2021 He, Zhang, Hao and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
He, Tianyu
Zhang, Xiaoyun
Hao, Jianyu
Ding, Shigang
Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
title Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
title_full Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
title_fullStr Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
title_full_unstemmed Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
title_short Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
title_sort phosphatase and tensin homolog in non-neoplastic digestive disease: more than just tumor suppressor
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204087/
https://www.ncbi.nlm.nih.gov/pubmed/34140896
http://dx.doi.org/10.3389/fphys.2021.684529
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