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Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios

Health effects induced by heavy metal components of particulate matter need further research. A total of 32 healthy volunteers were recruited to walk for 4 h in two different exposure scenarios in Wuhan from May 1 to Jun 30, 2019. Metabolomics technology was used to identify serum cardiovascular-rel...

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Autores principales: Liu, Feifei, Chen, Xiaolu, Liu, Yisi, Niu, Zhiping, Tang, Hong, Mao, Shuyuan, Li, Na, Chen, Gongbo, Xiang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204224/
https://www.ncbi.nlm.nih.gov/pubmed/33740723
http://dx.doi.org/10.1016/j.jhazmat.2021.125590
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author Liu, Feifei
Chen, Xiaolu
Liu, Yisi
Niu, Zhiping
Tang, Hong
Mao, Shuyuan
Li, Na
Chen, Gongbo
Xiang, Hao
author_facet Liu, Feifei
Chen, Xiaolu
Liu, Yisi
Niu, Zhiping
Tang, Hong
Mao, Shuyuan
Li, Na
Chen, Gongbo
Xiang, Hao
author_sort Liu, Feifei
collection PubMed
description Health effects induced by heavy metal components of particulate matter need further research. A total of 32 healthy volunteers were recruited to walk for 4 h in two different exposure scenarios in Wuhan from May 1 to Jun 30, 2019. Metabolomics technology was used to identify serum cardiovascular-related metabolites disturbance, and the health risk assessment model was employed to assess the non-carcinogenic and carcinogenic risks associated with airborne heavy metals. The results showed that the average mass concentrations of Co, Ni, Cd, Cu, Ag and Ba in PM(10) from May 1 to Jun 30, 2019 were 0.22, 0.49, 11.53, 2.23, 34.47 and 4.19 ng/m(3), respectively, and were 0.86, 128.47, 291.85, 291.94, 98.55 and 422.62 ng/m(3) in PM(2.5), respectively. Healthy young adults briefly exposed to heavy metals were associated with serum cardiovascular-related metabolites disturbance, including increased SM(d18:1/17:0) and Sphingomyelin, and decreased GlcCer(d16:1/18:0) and Galabiosylceramide, simultaneously accompanied by activation of the sphingolipid metabolism pathway. Non-carcinogenic and carcinogenic risks of airborne heavy metals via the inhalation route were observed, Ni and Cd most influenced to potential health risks. Findings indicated exposure to increment of heavy metals may increase health risks by causing cardiovascular-related metabolites disturbance via activating the sphingolipid metabolism pathway.
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spelling pubmed-82042242021-08-05 Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios Liu, Feifei Chen, Xiaolu Liu, Yisi Niu, Zhiping Tang, Hong Mao, Shuyuan Li, Na Chen, Gongbo Xiang, Hao J Hazard Mater Article Health effects induced by heavy metal components of particulate matter need further research. A total of 32 healthy volunteers were recruited to walk for 4 h in two different exposure scenarios in Wuhan from May 1 to Jun 30, 2019. Metabolomics technology was used to identify serum cardiovascular-related metabolites disturbance, and the health risk assessment model was employed to assess the non-carcinogenic and carcinogenic risks associated with airborne heavy metals. The results showed that the average mass concentrations of Co, Ni, Cd, Cu, Ag and Ba in PM(10) from May 1 to Jun 30, 2019 were 0.22, 0.49, 11.53, 2.23, 34.47 and 4.19 ng/m(3), respectively, and were 0.86, 128.47, 291.85, 291.94, 98.55 and 422.62 ng/m(3) in PM(2.5), respectively. Healthy young adults briefly exposed to heavy metals were associated with serum cardiovascular-related metabolites disturbance, including increased SM(d18:1/17:0) and Sphingomyelin, and decreased GlcCer(d16:1/18:0) and Galabiosylceramide, simultaneously accompanied by activation of the sphingolipid metabolism pathway. Non-carcinogenic and carcinogenic risks of airborne heavy metals via the inhalation route were observed, Ni and Cd most influenced to potential health risks. Findings indicated exposure to increment of heavy metals may increase health risks by causing cardiovascular-related metabolites disturbance via activating the sphingolipid metabolism pathway. Elsevier 2021-08-05 /pmc/articles/PMC8204224/ /pubmed/33740723 http://dx.doi.org/10.1016/j.jhazmat.2021.125590 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Feifei
Chen, Xiaolu
Liu, Yisi
Niu, Zhiping
Tang, Hong
Mao, Shuyuan
Li, Na
Chen, Gongbo
Xiang, Hao
Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios
title Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios
title_full Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios
title_fullStr Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios
title_full_unstemmed Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios
title_short Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios
title_sort serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204224/
https://www.ncbi.nlm.nih.gov/pubmed/33740723
http://dx.doi.org/10.1016/j.jhazmat.2021.125590
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