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Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA

[Image: see text] The unique ability of Mycobacterium tuberculosis (Mtb) to utilize host lipids such as cholesterol for survival, persistence, and virulence has made the metabolic pathway of cholesterol an area of great interest for therapeutics development. Herein, we identify and characterize two...

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Detalles Bibliográficos
Autores principales:	Yuan, Tianao, Werman, Joshua M., Yin, Xingyu, Yang, Meng, Garcia-Diaz, Miguel, Sampson, Nicole S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204306/ https://www.ncbi.nlm.nih.gov/pubmed/33826843 http://dx.doi.org/10.1021/acsinfecdis.1c00069

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