Cargando…

Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA

[Image: see text] The unique ability of Mycobacterium tuberculosis (Mtb) to utilize host lipids such as cholesterol for survival, persistence, and virulence has made the metabolic pathway of cholesterol an area of great interest for therapeutics development. Herein, we identify and characterize two...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Tianao, Werman, Joshua M., Yin, Xingyu, Yang, Meng, Garcia-Diaz, Miguel, Sampson, Nicole S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204306/ https://www.ncbi.nlm.nih.gov/pubmed/33826843 http://dx.doi.org/10.1021/acsinfecdis.1c00069

Ejemplares similares

Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 α(2)β(2) Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA
por: Yang, Meng, et al.
Publicado: (2015)

Cholest-5-ene
por: Khan, Mohd Shaheen, et al.
Publicado: (2011)

The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery
por: Yuan, Tianao, et al.
Publicado: (2021)

Cholest-5-en-7-one
por: Khan, Mohd. Shaheen, et al.
Publicado: (2010)

Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro
por: Nevi, Lorenzo, et al.
Publicado: (2019)

A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria
por: Werman, Joshua M., et al.
Publicado: (2023)

Dichloro(2,2′-bipyridine)copper/MAO: An Active and Stereospecific Catalyst for 1,3-Diene Polymerization
por: Ricci, Giovanni, et al.
Publicado: (2023)

Time Course Expression Analysis of 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole Induction of Cytoprotection in Human Endothelial Cells
por: Bynum, James A, et al.
Publicado: (2017)

3-Methyl-5α-cholest-2-ene
por: Ketuly, Kamal Aziz, et al.
Publicado: (2010)

A STUDY OF THE CROSS-REACTIVITY OF ANTIPURIN-6-OYL SERUM WITH DEOXYRIBONUCLEIC ACID (DNA)
por: Butler, Vincent P., et al.
Publicado: (1965)

Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL
por: Niu, Chi-Chien, et al.
Publicado: (2017)

3β-Chlorocholest-5-en-7-one
por: Khan, Mohd. Shaheen, et al.
Publicado: (2010)

Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin
por: Helmich, Kate E., et al.
Publicado: (2016)

1-(4-Bromophenyl)-3-(3-chloropropanoyl)thiourea
por: Abosadiya, Hamza M., et al.
Publicado: (2014)

Cholest-5-en-3β-yl N-phenylcarbamate
por: Graia, Mohsen, et al.
Publicado: (2009)

Comparative docking analysis of cholesterol analogs to ion channels to discriminate between stereospecific binding vs. stereospecific response
por: Barbera, Nicolas A., et al.
Publicado: (2019)

A second monoclinic polymorph of 3β-chlorocholest-5-ene
por: Khan, Mohd. Shaheen, et al.
Publicado: (2010)

The Cholesterol Metabolite Cholest-5-en-3-One Alleviates Hyperglycemia and Hyperinsulinemia in Obese (db/db) Mice
por: Nagao, Koji, et al.
Publicado: (2021)

3β-Chloro-N-methoxy-N-methylcholest-5-ene-24-carboxamide
por: González, Karilys, et al.
Publicado: (2012)

Stereospecific pharmacokinetic characterization of liquiritigenin in the rat
por: Alrushaid, Samaa, et al.
Publicado: (2017)

Ethane-1,2-diaminium 2,2′-[terephthaloylbis(azanediyl)]diacetate tetrahydrate
por: Pook, Niels-Patrick, et al.
Publicado: (2013)

Review on 422 Cataracts Done by "Smith's Method"
por: Trivedi, Ram Nath
Publicado: (1913)

Crystal structure of poly[[hexaaquatris(μ-3,6-dioxocyclohexa-1,4-diene-1,4-diolato)dierbium(III)] octadecahydrate]
por: Ponjan, Nutcha, et al.
Publicado: (2019)

Structural basis of stereospecific reduction by quinuclidinone reductase
por: Takeshita, Daijiro, et al.
Publicado: (2014)

Self-promoted and stereospecific formation of N-glycosides
por: Nielsen, Michael Martin, et al.
Publicado: (2019)

Stereospecific nucleophilic substitution at tertiary and quaternary stereocentres
por: Lanke, Veeranjaneyulu, et al.
Publicado: (2020)

Making chiral molecular knots and links stereospecifically
por: Wu, Huang, et al.
Publicado: (2023)

PM422. Creatine Phospho Kinase Elevations with Clozapine
por: Takahashi, Yuka
Publicado: (2016)

THU422 Laboratory Evaluation For Etiologies Of Secondary Osteoporosis
por: Shah, Nandi, et al.
Publicado: (2023)

Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes
por: Demming, Rebecca M., et al.
Publicado: (2018)

Production, Purification, and Identification of Cholest-4-en-3-one Produced by Cholesterol Oxidase from Rhodococcus sp. in Aqueous/Organic Biphasic System
por: Wu, Ke, et al.
Publicado: (2015)

N,N′-Bis(3β-acetoxy-5α-cholest-6-ylidene)hydrazine
por: Tabassum, Zishan, et al.
Publicado: (2011)

Hit Generation in TB Drug Discovery: From Genome to Granuloma
por: Yuan, Tianao, et al.
Publicado: (2018)

Correction to Hit Generation in TB Drug Discovery: From Genome to Granuloma
por: Yuan, Tianao, et al.
Publicado: (2019)

Rapid-reaction kinetics of the butyryl-CoA dehydrogenase component of the electron-bifurcating crotonyl-CoA-dependent NADH:ferredoxin oxidoreductase from Megasphaera elsdenii
por: Vigil, Wayne, et al.
Publicado: (2023)

A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters
por: Peter, Dominik M., et al.
Publicado: (2016)

42.2 INFLAMMATION AND GUT MICROBIOME IN FIRST-EPISODE PSYCHOSIS
por: Suvisaari, Jaana, et al.
Publicado: (2018)

Re‐evaluation of glycerol (E 422) as a food additive
por: Mortensen, Alicja, et al.
Publicado: (2017)

ODP422 PCOS is Associated with Increased Incidence of Co-morbidities
por: Vine, Donna, et al.
Publicado: (2022)

Cholest-5-en-3β-yl 3-(4-ethoxyphenyl)prop-2-enoate
por: Bugenhagen, Bernhard, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_u9ceonse9ivhd2cq22jtbk66h2