MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia

Amyotrophic lateral sclerosis and frontotemporal dementia are overlapping diseases in which MRI reveals brain structural changes in advance of symptom onset. Recapitulating these changes in preclinical models would help to improve our understanding of the molecular causes underlying regionally selec...

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Detalles Bibliográficos
Autores principales: Lin, Ziqiang, Kim, Eugene, Ahmed, Mohi, Han, Gang, Simmons, Camilla, Redhead, Yushi, Bartlett, Jack, Pena Altamira, Luis Emiliano, Callaghan, Isobel, White, Matthew A, Singh, Nisha, Sawiak, Stephen, Spires-Jones, Tara, Vernon, Anthony C, Coleman, Michael P, Green, Jeremy, Henstridge, Christopher, Davies, Jeffrey S, Cash, Diana, Sreedharan, Jemeen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204366/
https://www.ncbi.nlm.nih.gov/pubmed/34136812
http://dx.doi.org/10.1093/braincomms/fcab114

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