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Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

Immune receptors signal by recruiting (or tethering) enzymes to their cytoplasmic tails to catalyze reactions on substrates within reach. This is the case for the phosphatase SHP-1, which, upon tethering to inhibitory receptors, dephosphorylates diverse substrates to control T cell activation. Preci...

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Detalles Bibliográficos
Autores principales:	Clemens, Lara, Kutuzov, Mikhail, Bayer, Kristina Viktoria, Goyette, Jesse, Allard, Jun, Dushek, Omer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204385/ https://www.ncbi.nlm.nih.gov/pubmed/33781765 http://dx.doi.org/10.1016/j.bpj.2021.03.019

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