Cargando…

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

Immune receptors signal by recruiting (or tethering) enzymes to their cytoplasmic tails to catalyze reactions on substrates within reach. This is the case for the phosphatase SHP-1, which, upon tethering to inhibitory receptors, dephosphorylates diverse substrates to control T cell activation. Preci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clemens, Lara, Kutuzov, Mikhail, Bayer, Kristina Viktoria, Goyette, Jesse, Allard, Jun, Dushek, Omer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204385/ https://www.ncbi.nlm.nih.gov/pubmed/33781765 http://dx.doi.org/10.1016/j.bpj.2021.03.019

Ejemplares similares

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions
por: Zhang, Ying, et al.
Publicado: (2019)

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1
por: Goyette, Jesse, et al.
Publicado: (2017)

Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase
por: Markovics, Adrienn, et al.
Publicado: (2020)

Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization
por: Buck, Sara J. S., et al.
Publicado: (2022)

Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies
por: Song, Zhendong, et al.
Publicado: (2021)

Intrinsic Disorder in the T Cell Receptor Creates Cooperativity and Controls ZAP70 Binding
por: Clemens, Lara, et al.
Publicado: (2021)

The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis
por: Li, Yang, et al.
Publicado: (2019)

The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters
por: Qian, Yueping K, et al.
Publicado: (2008)

Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis
por: Liu, Xia, et al.
Publicado: (2011)

Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium
por: Yamashita, Hironori, et al.
Publicado: (2014)

Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2
por: Chen, Chuan, et al.
Publicado: (2015)

Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma
por: Hu, Zhongqian, et al.
Publicado: (2017)

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis
por: Heun, Yvonn, et al.
Publicado: (2019)

An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase
por: Anselmi, Massimiliano, et al.
Publicado: (2020)

The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
por: Saint-Laurent, Céline, et al.
Publicado: (2022)

The Allosteric Site on SHP2’s Protein Tyrosine Phosphatase Domain is Targetable with Druglike Small Molecules
por: Marsh-Armstrong, Brennan, et al.
Publicado: (2018)

Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine
por: Yarnall, Matthew T.N., et al.
Publicado: (2022)

Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice
por: Hu, Xiaopeng, et al.
Publicado: (2015)

Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2
por: Xia, L-x, et al.
Publicado: (2016)

Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria
por: Hsu, Ming-Fo, et al.
Publicado: (2017)

Role of the Tyrosine Phosphatase SHP-2 in Mediating Adrenomedullin Proangiogenic Activity in Solid Tumors
por: Sigaud, Romain, et al.
Publicado: (2021)

Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling
por: Tsai, Wan-Chen, et al.
Publicado: (2015)

A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma
por: Hu, Zhongqian, et al.
Publicado: (2015)

Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells
por: Raveendra-Panickar, Dhanya, et al.
Publicado: (2021)

Cx43 Promotes Endothelial Cell Migration and Angiogenesis via the Tyrosine Phosphatase SHP-2
por: Mannell, Hanna, et al.
Publicado: (2021)

Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells
por: Amante, Romain J., et al.
Publicado: (2022)

Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2
por: Solman, Maja, et al.
Publicado: (2022)

Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation
por: Kim, Dae Joon, et al.
Publicado: (2010)

Molecular flexibility of DNA as a key determinant of RAD51 recruitment
por: Paoletti, Federico, et al.
Publicado: (2020)

Sepsis-Induced Cardiac Mitochondrial Dysfunction Involves Altered Mitochondrial-Localization of Tyrosine Kinase Src and Tyrosine Phosphatase SHP2
por: Zang, Qun S., et al.
Publicado: (2012)

Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
por: Oriente, Francesco, et al.
Publicado: (2011)

Targeting a Cryptic Allosteric Site for Selective Inhibition of the Oncogenic Protein Tyrosine Phosphatase Shp2
por: Chio, Cynthia M., et al.
Publicado: (2014)

Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development
por: Idrees, Muhammad, et al.
Publicado: (2020)

Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells
por: Chen, Xin, et al.
Publicado: (2020)

Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1
por: Keilhack, Heike, et al.
Publicado: (2001)

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1
Publicado: (1996)

Design, Synthesis, Biological Activity and Molecular Dynamics Studies of Specific Protein Tyrosine Phosphatase 1B Inhibitors over SHP-2
por: Sun, Su-Xia, et al.
Publicado: (2013)

Exploring the Allosteric Mechanism of Src Homology-2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP2) by Molecular Dynamics Simulations
por: Wang, Quan, et al.
Publicado: (2020)

Tyrosine Phosphatase Shp2 Mediates the Estrogen Biological Action in Breast Cancer via Interaction with the Estrogen Extranuclear Receptor
por: Li, Jun, et al.
Publicado: (2014)

The tyrosine phosphatase SHP-2 dephosphorylated by ALV-J via its Env efficiently promotes ALV-J replication
por: Li, Tuofan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ivhastb2nrgjcqauep6g6ma0qj