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Energetics and structure of alanine-rich α-helices via adaptive steered molecular dynamics
The energetics and hydrogen bonding profiles of the helix-to-coil transition were found to be an additive property and to increase linearly with chain length, respectively, in alanine-rich α-helical peptides. A model system of polyalanine repeats was used to establish this hypothesis for the energet...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204395/ https://www.ncbi.nlm.nih.gov/pubmed/33775636 http://dx.doi.org/10.1016/j.bpj.2021.03.017 |