Adenosine deaminase negative pleural tuberculosis: a case report

BACKGROUND: A pleural fluid adenosine deaminase (ADA) has been used globally to assist in the diagnosis of a tuberculous pleural effusion (TPE) with a notable negative predictive value. CASE PRESENTATION: We report a case of a patient with a negative pleural fluid ADA who was found to have culture-p...

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Autores principales: Boggs, Zachary H., Heysell, Scott, Eby, Joshua, Arnold, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204465/
https://www.ncbi.nlm.nih.gov/pubmed/34130662
http://dx.doi.org/10.1186/s12879-021-06276-4
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author Boggs, Zachary H.
Heysell, Scott
Eby, Joshua
Arnold, Christopher
author_facet Boggs, Zachary H.
Heysell, Scott
Eby, Joshua
Arnold, Christopher
author_sort Boggs, Zachary H.
collection PubMed
description BACKGROUND: A pleural fluid adenosine deaminase (ADA) has been used globally to assist in the diagnosis of a tuberculous pleural effusion (TPE) with a notable negative predictive value. CASE PRESENTATION: We report a case of a patient with a negative pleural fluid ADA who was found to have culture-positive and biopsy-proven Mycobacterium tuberculosis. CONCLUSIONS: This case shows the importance of pursuing gold standard diagnostic studies when clinical suspicion remains high despite negative preliminary testing. We further describe gaps in research to improve pleural fluid biomarkers for TPE.
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spelling pubmed-82044652021-06-16 Adenosine deaminase negative pleural tuberculosis: a case report Boggs, Zachary H. Heysell, Scott Eby, Joshua Arnold, Christopher BMC Infect Dis Case Report BACKGROUND: A pleural fluid adenosine deaminase (ADA) has been used globally to assist in the diagnosis of a tuberculous pleural effusion (TPE) with a notable negative predictive value. CASE PRESENTATION: We report a case of a patient with a negative pleural fluid ADA who was found to have culture-positive and biopsy-proven Mycobacterium tuberculosis. CONCLUSIONS: This case shows the importance of pursuing gold standard diagnostic studies when clinical suspicion remains high despite negative preliminary testing. We further describe gaps in research to improve pleural fluid biomarkers for TPE. BioMed Central 2021-06-15 /pmc/articles/PMC8204465/ /pubmed/34130662 http://dx.doi.org/10.1186/s12879-021-06276-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Boggs, Zachary H.
Heysell, Scott
Eby, Joshua
Arnold, Christopher
Adenosine deaminase negative pleural tuberculosis: a case report
title Adenosine deaminase negative pleural tuberculosis: a case report
title_full Adenosine deaminase negative pleural tuberculosis: a case report
title_fullStr Adenosine deaminase negative pleural tuberculosis: a case report
title_full_unstemmed Adenosine deaminase negative pleural tuberculosis: a case report
title_short Adenosine deaminase negative pleural tuberculosis: a case report
title_sort adenosine deaminase negative pleural tuberculosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204465/
https://www.ncbi.nlm.nih.gov/pubmed/34130662
http://dx.doi.org/10.1186/s12879-021-06276-4
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