Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model

BACKGROUND: Neuronal hyperactivity related to β-amyloid (Aβ) is considered an early warning sign of Alzheimer disease (AD). Although increasing evidence supports this opinion, the underlying mechanisms are still unknown. METHODS: Here, we recorded whole-cell synaptic currents and membrane potentials...

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Detalles Bibliográficos
Autores principales: Li, Yang, Zhu, Ke, Li, Ning, Wang, Xiaotong, Xiao, Xuansheng, Li, Linying, Li, Lijuan, He, Ying, Zhang, Jinglan, Wo, Jiaoyang, Cui, Yanqiu, Huang, Haixia, Zhang, Jianliang, Wang, Wei, Wang, Xiaomin, Zheng, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204558/
https://www.ncbi.nlm.nih.gov/pubmed/34127063
http://dx.doi.org/10.1186/s13195-021-00859-8

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