Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines

Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Ja...

Descripción completa

Detalles Bibliográficos
Autores principales: Hwang, Jimin, Lee, Se Bee, Lee, Seung Won, Lee, Min Ho, Koyanagi, Ai, Jacob, Louis, Tizaoui, Kalthoum, Yon, Dong Keon, Shin, Jae Il, Smith, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204660/
https://www.ncbi.nlm.nih.gov/pubmed/34139631
http://dx.doi.org/10.1016/j.jaut.2021.102681
_version_ 1783708378738982912
author Hwang, Jimin
Lee, Se Bee
Lee, Seung Won
Lee, Min Ho
Koyanagi, Ai
Jacob, Louis
Tizaoui, Kalthoum
Yon, Dong Keon
Shin, Jae Il
Smith, Lee
author_facet Hwang, Jimin
Lee, Se Bee
Lee, Seung Won
Lee, Min Ho
Koyanagi, Ai
Jacob, Louis
Tizaoui, Kalthoum
Yon, Dong Keon
Shin, Jae Il
Smith, Lee
author_sort Hwang, Jimin
collection PubMed
description Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination.
format Online
Article
Text
id pubmed-8204660
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-82046602021-06-15 Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines Hwang, Jimin Lee, Se Bee Lee, Seung Won Lee, Min Ho Koyanagi, Ai Jacob, Louis Tizaoui, Kalthoum Yon, Dong Keon Shin, Jae Il Smith, Lee J Autoimmun Article Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination. Elsevier Ltd. 2021-08 2021-06-15 /pmc/articles/PMC8204660/ /pubmed/34139631 http://dx.doi.org/10.1016/j.jaut.2021.102681 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hwang, Jimin
Lee, Se Bee
Lee, Seung Won
Lee, Min Ho
Koyanagi, Ai
Jacob, Louis
Tizaoui, Kalthoum
Yon, Dong Keon
Shin, Jae Il
Smith, Lee
Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines
title Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines
title_full Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines
title_fullStr Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines
title_full_unstemmed Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines
title_short Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines
title_sort comparison of vaccine-induced thrombotic events between chadox1 ncov-19 and ad26.cov.2.s vaccines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204660/
https://www.ncbi.nlm.nih.gov/pubmed/34139631
http://dx.doi.org/10.1016/j.jaut.2021.102681
work_keys_str_mv AT hwangjimin comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT leesebee comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT leeseungwon comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT leeminho comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT koyanagiai comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT jacoblouis comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT tizaouikalthoum comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT yondongkeon comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT shinjaeil comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines
AT smithlee comparisonofvaccineinducedthromboticeventsbetweenchadox1ncov19andad26cov2svaccines

Ejemplares similares