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Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19

BACKGROUND: In the coronavirus disease 2019 (COVID-19) global pandemic, patients with cardiovascular disease represent a vulnerable population with higher risk for contracting COVID-19 and worse prognosis with higher case fatality rates. However, the relationship between COVID-19 and heart failure (...

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Autores principales: Ruge, Max, Gomez, Joanne Michelle D., du Fay de Lavallaz, Jeanne, Hlepas, Alexander, Rahman, Annas, Patel, Priya, Hoster, Clay, Lavani, Prutha, Nair, Gatha G., Jahan, Nusrat, Alan Simmons, J., Rao, Anupama K., Cotts, William, Williams, Kim, Volgman, Annabelle Santos, Marinescu, Karolina, Suboc, Tisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204812/
https://www.ncbi.nlm.nih.gov/pubmed/34151308
http://dx.doi.org/10.1016/j.ahjo.2021.100022
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author Ruge, Max
Gomez, Joanne Michelle D.
du Fay de Lavallaz, Jeanne
Hlepas, Alexander
Rahman, Annas
Patel, Priya
Hoster, Clay
Lavani, Prutha
Nair, Gatha G.
Jahan, Nusrat
Alan Simmons, J.
Rao, Anupama K.
Cotts, William
Williams, Kim
Volgman, Annabelle Santos
Marinescu, Karolina
Suboc, Tisha
author_facet Ruge, Max
Gomez, Joanne Michelle D.
du Fay de Lavallaz, Jeanne
Hlepas, Alexander
Rahman, Annas
Patel, Priya
Hoster, Clay
Lavani, Prutha
Nair, Gatha G.
Jahan, Nusrat
Alan Simmons, J.
Rao, Anupama K.
Cotts, William
Williams, Kim
Volgman, Annabelle Santos
Marinescu, Karolina
Suboc, Tisha
author_sort Ruge, Max
collection PubMed
description BACKGROUND: In the coronavirus disease 2019 (COVID-19) global pandemic, patients with cardiovascular disease represent a vulnerable population with higher risk for contracting COVID-19 and worse prognosis with higher case fatality rates. However, the relationship between COVID-19 and heart failure (HF) is unclear, specifically whether HF is an independent risk factor for severe infection or if other accompanying comorbidities are responsible for the increased risk. METHODS: This is a retrospective analysis of 1331 adult patients diagnosed with COVID-19 infection between March and June 2020 admitted at Rush University System for Health (RUSH) in metropolitan Chicago, Illinois, USA. Patients with history of HF were identified by International Classification of Disease, Tenth Revision (ICD-10) code assignments extracted from the electronic medical record. Propensity score matching was utilized to control for the numerous confounders, and univariable logistic regression was performed to assess the relationship between HF and 60-day morbidity and mortality outcomes. RESULTS: The propensity score matched cohort consisted of 188 patients in both the HF and no HF groups. HF patients did not have lower 60-day mortality (OR 0.81; p = 0.43) compared to patients without HF. However, those with HF were more likely to require readmission within 60 days (OR 2.88; p < 0.001) and sustain myocardial injury defined as troponin elevation within 60 days (OR 3.14; p < 0.05). CONCLUSIONS: This study highlights the complex network of confounders present between HF and COVID-19. When balanced for these numerous factors, those with HF appear to be at no higher risk of 60-day mortality from COVID-19 but are at increased risk for morbidity.
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spelling pubmed-82048122021-06-16 Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19 Ruge, Max Gomez, Joanne Michelle D. du Fay de Lavallaz, Jeanne Hlepas, Alexander Rahman, Annas Patel, Priya Hoster, Clay Lavani, Prutha Nair, Gatha G. Jahan, Nusrat Alan Simmons, J. Rao, Anupama K. Cotts, William Williams, Kim Volgman, Annabelle Santos Marinescu, Karolina Suboc, Tisha Am Heart J Plus Research Paper BACKGROUND: In the coronavirus disease 2019 (COVID-19) global pandemic, patients with cardiovascular disease represent a vulnerable population with higher risk for contracting COVID-19 and worse prognosis with higher case fatality rates. However, the relationship between COVID-19 and heart failure (HF) is unclear, specifically whether HF is an independent risk factor for severe infection or if other accompanying comorbidities are responsible for the increased risk. METHODS: This is a retrospective analysis of 1331 adult patients diagnosed with COVID-19 infection between March and June 2020 admitted at Rush University System for Health (RUSH) in metropolitan Chicago, Illinois, USA. Patients with history of HF were identified by International Classification of Disease, Tenth Revision (ICD-10) code assignments extracted from the electronic medical record. Propensity score matching was utilized to control for the numerous confounders, and univariable logistic regression was performed to assess the relationship between HF and 60-day morbidity and mortality outcomes. RESULTS: The propensity score matched cohort consisted of 188 patients in both the HF and no HF groups. HF patients did not have lower 60-day mortality (OR 0.81; p = 0.43) compared to patients without HF. However, those with HF were more likely to require readmission within 60 days (OR 2.88; p < 0.001) and sustain myocardial injury defined as troponin elevation within 60 days (OR 3.14; p < 0.05). CONCLUSIONS: This study highlights the complex network of confounders present between HF and COVID-19. When balanced for these numerous factors, those with HF appear to be at no higher risk of 60-day mortality from COVID-19 but are at increased risk for morbidity. The Author(s). Published by Elsevier Inc. 2021-04 2021-06-15 /pmc/articles/PMC8204812/ /pubmed/34151308 http://dx.doi.org/10.1016/j.ahjo.2021.100022 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Paper
Ruge, Max
Gomez, Joanne Michelle D.
du Fay de Lavallaz, Jeanne
Hlepas, Alexander
Rahman, Annas
Patel, Priya
Hoster, Clay
Lavani, Prutha
Nair, Gatha G.
Jahan, Nusrat
Alan Simmons, J.
Rao, Anupama K.
Cotts, William
Williams, Kim
Volgman, Annabelle Santos
Marinescu, Karolina
Suboc, Tisha
Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19
title Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19
title_full Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19
title_fullStr Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19
title_full_unstemmed Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19
title_short Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19
title_sort impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with covid-19
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204812/
https://www.ncbi.nlm.nih.gov/pubmed/34151308
http://dx.doi.org/10.1016/j.ahjo.2021.100022
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