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Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus

Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired β-pancreatic cell function...

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Autores principales: Ramírez-Alarcón, Karina, Victoriano, Montserrat, Mardones, Lorena, Villagran, Marcelo, Al-Harrasi, Ahmed, Al-Rawahi, Ahmed, Cruz-Martins, Natália, Sharifi-Rad, Javad, Martorell, Miquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204854/
https://www.ncbi.nlm.nih.gov/pubmed/34140928
http://dx.doi.org/10.3389/fendo.2021.656978
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author Ramírez-Alarcón, Karina
Victoriano, Montserrat
Mardones, Lorena
Villagran, Marcelo
Al-Harrasi, Ahmed
Al-Rawahi, Ahmed
Cruz-Martins, Natália
Sharifi-Rad, Javad
Martorell, Miquel
author_facet Ramírez-Alarcón, Karina
Victoriano, Montserrat
Mardones, Lorena
Villagran, Marcelo
Al-Harrasi, Ahmed
Al-Rawahi, Ahmed
Cruz-Martins, Natália
Sharifi-Rad, Javad
Martorell, Miquel
author_sort Ramírez-Alarcón, Karina
collection PubMed
description Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired β-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, and recently the epigenetic regulation of β-pancreatic cells differentiation has been underlined as being involved. It is currently known that several bioactive molecules, widely abundant in plants used as food or infusions, have a key role in histone modification and DNA methylation, and constituted potential epidrugs candidates against T2DM. In this sense, in this review the epigenetic mechanisms involved in T2DM and protein targets are reviewed, with special focus in studies addressing the potential use of phytochemicals as epidrugs that prevent and/or control T2DM in vivo and in vitro. As main findings, and although some controversial results have been found, bioactive molecules with epigenetic regulatory function, appear to be a potential replacement/complementary therapy of pharmacological hypoglycemic drugs, with minimal side effects. Indeed, natural epidrugs have shown to prevent or delay the T2DM development and the morbidity associated to dysfunction of blood vessels, eyes and kidneys due to sustained hyperglycemia in T2DM patients.
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spelling pubmed-82048542021-06-16 Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus Ramírez-Alarcón, Karina Victoriano, Montserrat Mardones, Lorena Villagran, Marcelo Al-Harrasi, Ahmed Al-Rawahi, Ahmed Cruz-Martins, Natália Sharifi-Rad, Javad Martorell, Miquel Front Endocrinol (Lausanne) Endocrinology Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired β-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, and recently the epigenetic regulation of β-pancreatic cells differentiation has been underlined as being involved. It is currently known that several bioactive molecules, widely abundant in plants used as food or infusions, have a key role in histone modification and DNA methylation, and constituted potential epidrugs candidates against T2DM. In this sense, in this review the epigenetic mechanisms involved in T2DM and protein targets are reviewed, with special focus in studies addressing the potential use of phytochemicals as epidrugs that prevent and/or control T2DM in vivo and in vitro. As main findings, and although some controversial results have been found, bioactive molecules with epigenetic regulatory function, appear to be a potential replacement/complementary therapy of pharmacological hypoglycemic drugs, with minimal side effects. Indeed, natural epidrugs have shown to prevent or delay the T2DM development and the morbidity associated to dysfunction of blood vessels, eyes and kidneys due to sustained hyperglycemia in T2DM patients. Frontiers Media S.A. 2021-06-01 /pmc/articles/PMC8204854/ /pubmed/34140928 http://dx.doi.org/10.3389/fendo.2021.656978 Text en Copyright © 2021 Ramírez-Alarcón, Victoriano, Mardones, Villagran, Al-Harrasi, Al-Rawahi, Cruz-Martins, Sharifi-Rad and Martorell https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ramírez-Alarcón, Karina
Victoriano, Montserrat
Mardones, Lorena
Villagran, Marcelo
Al-Harrasi, Ahmed
Al-Rawahi, Ahmed
Cruz-Martins, Natália
Sharifi-Rad, Javad
Martorell, Miquel
Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
title Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
title_full Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
title_fullStr Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
title_full_unstemmed Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
title_short Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
title_sort phytochemicals as potential epidrugs in type 2 diabetes mellitus
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204854/
https://www.ncbi.nlm.nih.gov/pubmed/34140928
http://dx.doi.org/10.3389/fendo.2021.656978
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