Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism‐like phenotype

The key role of APP for Alzheimer pathogenesis is well established. However, perinatal lethality of germline knockout mice lacking the entire APP family has so far precluded the analysis of its physiological functions for the developing and adult brain. Here, we generated conditional APP/APLP1/APLP2...

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Detalles Bibliográficos
Autores principales: Steubler, Vicky, Erdinger, Susanne, Back, Michaela K, Ludewig, Susann, Fässler, Dominique, Richter, Max, Han, Kang, Slomianka, Lutz, Amrein, Irmgard, von Engelhardt, Jakob, Wolfer, David P, Korte, Martin, Müller, Ulrike C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204861/
https://www.ncbi.nlm.nih.gov/pubmed/34008862
http://dx.doi.org/10.15252/embj.2020107471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204861/
https://www.ncbi.nlm.nih.gov/pubmed/34008862
http://dx.doi.org/10.15252/embj.2020107471

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