Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir

[Image: see text] SARS-CoV-2 main protease (M(pro)) is a cysteine protease that mediates the cleavage of viral polyproteins and is a validated antiviral drug target. M(pro) is highly conserved among all seven human coronaviruses, with certain M(pro) inhibitors having broad-spectrum antiviral activit...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Zilei, Sacco, Michael, Hu, Yanmei, Ma, Chunlong, Meng, Xiangzhi, Zhang, Fushun, Szeto, Tommy, Xiang, Yan, Chen, Yu, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204911/
https://www.ncbi.nlm.nih.gov/pubmed/34414360
http://dx.doi.org/10.1021/acsptsci.1c00099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204911/
https://www.ncbi.nlm.nih.gov/pubmed/34414360
http://dx.doi.org/10.1021/acsptsci.1c00099

Ejemplares similares