Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease

Activation of macroautophagy/autophagy, a key mechanism involved in the degradation and removal of aggregated proteins, can successfully reverse Huntington disease phenotypes in various model systems. How neuronal autophagy impairments need to be considered in Huntington disease progression to achie...

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Detalles Bibliográficos
Autores principales: Brattås, Per Ludvik, Hersbach, Bob A., Madsen, Sofia, Petri, Rebecca, Jakobsson, Johan, Pircs, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204969/
https://www.ncbi.nlm.nih.gov/pubmed/32374203
http://dx.doi.org/10.1080/15548627.2020.1760014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204969/
https://www.ncbi.nlm.nih.gov/pubmed/32374203
http://dx.doi.org/10.1080/15548627.2020.1760014

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