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Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease
Activation of macroautophagy/autophagy, a key mechanism involved in the degradation and removal of aggregated proteins, can successfully reverse Huntington disease phenotypes in various model systems. How neuronal autophagy impairments need to be considered in Huntington disease progression to achie...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204969/ https://www.ncbi.nlm.nih.gov/pubmed/32374203 http://dx.doi.org/10.1080/15548627.2020.1760014 |