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Identifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodies
Understanding the pharmacokinetic (PK) properties of a drug, such as clearance, is a crucial step for evaluating efficacy. The PK of therapeutic antibodies can be complex and is influenced by interactions with the target, Fc-receptors, anti-drug antibodies, and antibody intrinsic factors. A growing...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204999/ https://www.ncbi.nlm.nih.gov/pubmed/34116620 http://dx.doi.org/10.1080/19420862.2021.1932230 |