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Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link betwee...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205122/ https://www.ncbi.nlm.nih.gov/pubmed/34129621 http://dx.doi.org/10.1371/journal.pone.0253257 |
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author | Woo, Ho Geol Chang, Yoonkyung Lee, Ji Sung Song, Tae-Jin |
author_facet | Woo, Ho Geol Chang, Yoonkyung Lee, Ji Sung Song, Tae-Jin |
author_sort | Woo, Ho Geol |
collection | PubMed |
description | Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link between tooth loss and the risk of hypertension. From the national health insurance system-health screening cohort in Korea, 19,680 participants who underwent three or more health examinations, including blood pressure measurements, between January 2003 and December 2008, without any history or diagnosis of hypertension were included in this study. Hypertension was defined as the diagnosis of hypertension (International Classification of Diseases-10 code “I10–11”) accompanied by the prescription of an antihypertensive agent or at least one health examination result of blood pressure of ≥140/90 mmHg. Kaplan-Meier survival curves with the log-rank test were used to evaluate the relationship between oral hygiene indicators and the incidence of hypertension. Cox proportional hazard models were applied to determine the association between oral hygiene indicators and the development of hypertension. During a median follow-up of 7.4 years, 1,853 patients developed hypertension. The estimated incidence of hypertension within seven years was 8.8%. Multivariable analysis confirmed a significant relationship between the number of lost teeth and hypertension (hazard ratio: 2.26; 95% confidence interval [1.24–4.10], p = 0.007, p for trend = 0.005). There was a positive association between the number of lost teeth and the risk of hypertension in a longitudinal research. In conclusion, the number of lost teeth may be associated with the risk of development of hypertension. |
format | Online Article Text |
id | pubmed-8205122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-82051222021-06-29 Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study Woo, Ho Geol Chang, Yoonkyung Lee, Ji Sung Song, Tae-Jin PLoS One Research Article Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link between tooth loss and the risk of hypertension. From the national health insurance system-health screening cohort in Korea, 19,680 participants who underwent three or more health examinations, including blood pressure measurements, between January 2003 and December 2008, without any history or diagnosis of hypertension were included in this study. Hypertension was defined as the diagnosis of hypertension (International Classification of Diseases-10 code “I10–11”) accompanied by the prescription of an antihypertensive agent or at least one health examination result of blood pressure of ≥140/90 mmHg. Kaplan-Meier survival curves with the log-rank test were used to evaluate the relationship between oral hygiene indicators and the incidence of hypertension. Cox proportional hazard models were applied to determine the association between oral hygiene indicators and the development of hypertension. During a median follow-up of 7.4 years, 1,853 patients developed hypertension. The estimated incidence of hypertension within seven years was 8.8%. Multivariable analysis confirmed a significant relationship between the number of lost teeth and hypertension (hazard ratio: 2.26; 95% confidence interval [1.24–4.10], p = 0.007, p for trend = 0.005). There was a positive association between the number of lost teeth and the risk of hypertension in a longitudinal research. In conclusion, the number of lost teeth may be associated with the risk of development of hypertension. Public Library of Science 2021-06-15 /pmc/articles/PMC8205122/ /pubmed/34129621 http://dx.doi.org/10.1371/journal.pone.0253257 Text en © 2021 Woo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Woo, Ho Geol Chang, Yoonkyung Lee, Ji Sung Song, Tae-Jin Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study |
title | Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study |
title_full | Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study |
title_fullStr | Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study |
title_full_unstemmed | Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study |
title_short | Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study |
title_sort | tooth loss is associated with an increased risk of hypertension: a nationwide population-based cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205122/ https://www.ncbi.nlm.nih.gov/pubmed/34129621 http://dx.doi.org/10.1371/journal.pone.0253257 |
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