Cargando…

Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study

Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link betwee...

Descripción completa

Detalles Bibliográficos
Autores principales: Woo, Ho Geol, Chang, Yoonkyung, Lee, Ji Sung, Song, Tae-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205122/
https://www.ncbi.nlm.nih.gov/pubmed/34129621
http://dx.doi.org/10.1371/journal.pone.0253257
_version_ 1783708445496573952
author Woo, Ho Geol
Chang, Yoonkyung
Lee, Ji Sung
Song, Tae-Jin
author_facet Woo, Ho Geol
Chang, Yoonkyung
Lee, Ji Sung
Song, Tae-Jin
author_sort Woo, Ho Geol
collection PubMed
description Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link between tooth loss and the risk of hypertension. From the national health insurance system-health screening cohort in Korea, 19,680 participants who underwent three or more health examinations, including blood pressure measurements, between January 2003 and December 2008, without any history or diagnosis of hypertension were included in this study. Hypertension was defined as the diagnosis of hypertension (International Classification of Diseases-10 code “I10–11”) accompanied by the prescription of an antihypertensive agent or at least one health examination result of blood pressure of ≥140/90 mmHg. Kaplan-Meier survival curves with the log-rank test were used to evaluate the relationship between oral hygiene indicators and the incidence of hypertension. Cox proportional hazard models were applied to determine the association between oral hygiene indicators and the development of hypertension. During a median follow-up of 7.4 years, 1,853 patients developed hypertension. The estimated incidence of hypertension within seven years was 8.8%. Multivariable analysis confirmed a significant relationship between the number of lost teeth and hypertension (hazard ratio: 2.26; 95% confidence interval [1.24–4.10], p = 0.007, p for trend = 0.005). There was a positive association between the number of lost teeth and the risk of hypertension in a longitudinal research. In conclusion, the number of lost teeth may be associated with the risk of development of hypertension.
format Online
Article
Text
id pubmed-8205122
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-82051222021-06-29 Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study Woo, Ho Geol Chang, Yoonkyung Lee, Ji Sung Song, Tae-Jin PLoS One Research Article Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link between tooth loss and the risk of hypertension. From the national health insurance system-health screening cohort in Korea, 19,680 participants who underwent three or more health examinations, including blood pressure measurements, between January 2003 and December 2008, without any history or diagnosis of hypertension were included in this study. Hypertension was defined as the diagnosis of hypertension (International Classification of Diseases-10 code “I10–11”) accompanied by the prescription of an antihypertensive agent or at least one health examination result of blood pressure of ≥140/90 mmHg. Kaplan-Meier survival curves with the log-rank test were used to evaluate the relationship between oral hygiene indicators and the incidence of hypertension. Cox proportional hazard models were applied to determine the association between oral hygiene indicators and the development of hypertension. During a median follow-up of 7.4 years, 1,853 patients developed hypertension. The estimated incidence of hypertension within seven years was 8.8%. Multivariable analysis confirmed a significant relationship between the number of lost teeth and hypertension (hazard ratio: 2.26; 95% confidence interval [1.24–4.10], p = 0.007, p for trend = 0.005). There was a positive association between the number of lost teeth and the risk of hypertension in a longitudinal research. In conclusion, the number of lost teeth may be associated with the risk of development of hypertension. Public Library of Science 2021-06-15 /pmc/articles/PMC8205122/ /pubmed/34129621 http://dx.doi.org/10.1371/journal.pone.0253257 Text en © 2021 Woo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Woo, Ho Geol
Chang, Yoonkyung
Lee, Ji Sung
Song, Tae-Jin
Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
title Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
title_full Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
title_fullStr Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
title_full_unstemmed Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
title_short Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
title_sort tooth loss is associated with an increased risk of hypertension: a nationwide population-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205122/
https://www.ncbi.nlm.nih.gov/pubmed/34129621
http://dx.doi.org/10.1371/journal.pone.0253257
work_keys_str_mv AT woohogeol toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy
AT changyoonkyung toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy
AT leejisung toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy
AT songtaejin toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy