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Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic

BACKGROUND: The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large aneurysms reduces ruptures and AAA-related mortality. AAA screening services...

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Autores principales: Kim, Lois G., Sweeting, Michael J., Armer, Morag, Jacomelli, Jo, Nasim, Akhtar, Harrison, Seamus C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205127/
https://www.ncbi.nlm.nih.gov/pubmed/34129649
http://dx.doi.org/10.1371/journal.pone.0253327
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author Kim, Lois G.
Sweeting, Michael J.
Armer, Morag
Jacomelli, Jo
Nasim, Akhtar
Harrison, Seamus C.
author_facet Kim, Lois G.
Sweeting, Michael J.
Armer, Morag
Jacomelli, Jo
Nasim, Akhtar
Harrison, Seamus C.
author_sort Kim, Lois G.
collection PubMed
description BACKGROUND: The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large aneurysms reduces ruptures and AAA-related mortality. AAA screening services have been disrupted following COVID-19 but it is not known how this may impact AAA-related mortality, or where efforts should be focussed as services resume. METHODS: We repurposed a previously validated discrete event simulation model to investigate the impact of COVID-19-related service disruption on key outcomes. This model was used to explore the impact of delayed invitation and reduced attendance in men invited to screening. Additionally, we investigated the impact of temporarily suspending scans, increasing the threshold for elective surgery to 7cm and increasing drop-out in the AAA cohort under surveillance, using data from NAAASP to inform the population. FINDINGS: Delaying invitation to primary screening up to two years had little impact on key outcomes whereas a 10% reduction in attendance could lead to a 2% lifetime increase in AAA-related deaths. In surveillance patients, a 1-year suspension of surveillance or increase in the elective threshold resulted in a 0.4% increase in excess AAA-related deaths (8% in those 5–5.4cm at the start). Longer suspensions or a doubling of drop-out from surveillance would have a pronounced impact on outcomes. INTERPRETATION: Efforts should be directed towards encouraging men to attend AAA screening service appointments post-COVID-19. Those with AAAs on surveillance should be prioritised as the screening programme resumes, as changes to these services beyond one year are likely to have a larger impact on surgical burden and AAA-related mortality.
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spelling pubmed-82051272021-06-29 Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic Kim, Lois G. Sweeting, Michael J. Armer, Morag Jacomelli, Jo Nasim, Akhtar Harrison, Seamus C. PLoS One Research Article BACKGROUND: The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large aneurysms reduces ruptures and AAA-related mortality. AAA screening services have been disrupted following COVID-19 but it is not known how this may impact AAA-related mortality, or where efforts should be focussed as services resume. METHODS: We repurposed a previously validated discrete event simulation model to investigate the impact of COVID-19-related service disruption on key outcomes. This model was used to explore the impact of delayed invitation and reduced attendance in men invited to screening. Additionally, we investigated the impact of temporarily suspending scans, increasing the threshold for elective surgery to 7cm and increasing drop-out in the AAA cohort under surveillance, using data from NAAASP to inform the population. FINDINGS: Delaying invitation to primary screening up to two years had little impact on key outcomes whereas a 10% reduction in attendance could lead to a 2% lifetime increase in AAA-related deaths. In surveillance patients, a 1-year suspension of surveillance or increase in the elective threshold resulted in a 0.4% increase in excess AAA-related deaths (8% in those 5–5.4cm at the start). Longer suspensions or a doubling of drop-out from surveillance would have a pronounced impact on outcomes. INTERPRETATION: Efforts should be directed towards encouraging men to attend AAA screening service appointments post-COVID-19. Those with AAAs on surveillance should be prioritised as the screening programme resumes, as changes to these services beyond one year are likely to have a larger impact on surgical burden and AAA-related mortality. Public Library of Science 2021-06-15 /pmc/articles/PMC8205127/ /pubmed/34129649 http://dx.doi.org/10.1371/journal.pone.0253327 Text en © 2021 Kim et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kim, Lois G.
Sweeting, Michael J.
Armer, Morag
Jacomelli, Jo
Nasim, Akhtar
Harrison, Seamus C.
Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic
title Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic
title_full Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic
title_fullStr Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic
title_full_unstemmed Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic
title_short Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic
title_sort modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in england during the covid-19 pandemic
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205127/
https://www.ncbi.nlm.nih.gov/pubmed/34129649
http://dx.doi.org/10.1371/journal.pone.0253327
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