A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA

The most frequent genetic alteration in acute myeloid leukemia (AML) is the mutation of nucleophosmin 1 (NPM1). Yet, its downstream oncogenic routes are not fully understood. Here, we report the identification of one long noncoding RNA (lncRNA) overexpressed in NPM1-mutated AML patients (named LONA)...

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Detalles Bibliográficos
Autores principales: Gourvest, Morgane, De Clara, Etienne, Wu, Hsin-Chieh, Touriol, Christian, Meggetto, Fabienne, De Thé, Hugues, Pyronnet, Stéphane, Brousset, Pierre, Bousquet, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205207/
https://www.ncbi.nlm.nih.gov/pubmed/34131282
http://dx.doi.org/10.1038/s41375-021-01307-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205207/
https://www.ncbi.nlm.nih.gov/pubmed/34131282
http://dx.doi.org/10.1038/s41375-021-01307-0

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