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HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants

[Image: see text] Integrase strand transfer inhibitors (INSTIs) block the integration step of the retroviral lifecycle and are first-line drugs used for the treatment of HIV-1/AIDS. INSTIs have a polycyclic core with heteroatom triads, chelate the metal ions at the active site, and have a halobenzyl...

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Detalles Bibliográficos
Autores principales:	Smith, Steven J., Zhao, Xue Zhi, Passos, Dario Oliveira, Pye, Valerie E., Cherepanov, Peter, Lyumkis, Dmitry, Burke, Terrence R., Hughes, Stephen H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205226/ https://www.ncbi.nlm.nih.gov/pubmed/33686850 http://dx.doi.org/10.1021/acsinfecdis.0c00819

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