Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity

[Image: see text] Coenzyme A (CoA) is a ubiquitous cofactor present in all living cells and estimated to be required for up to 9% of intracellular enzymatic reactions. Mycobacterium tuberculosis (Mtb) relies on its own ability to biosynthesize CoA to meet the needs of the myriad enzymatic reactions...

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Detalles Bibliográficos
Autores principales: Evans, Joanna C., Murugesan, Dinakaran, Post, John M., Mendes, Vitor, Wang, Zhe, Nahiyaan, Navid, Lynch, Sasha L., Thompson, Stephen, Green, Simon R., Ray, Peter C., Hess, Jeannine, Spry, Christina, Coyne, Anthony G., Abell, Chris, Boshoff, Helena I. M., Wyatt, Paul G., Rhee, Kyu Y., Blundell, Tom L., Barry, Clifton E., Mizrahi, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205227/
https://www.ncbi.nlm.nih.gov/pubmed/33939919
http://dx.doi.org/10.1021/acsinfecdis.0c00904

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