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Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory
Africa’s readiness to respond to the SARS-COV-2 pandemic was tested due to reliance on rapid turn-around-time of polymerase chain reaction results for clinical management, isolation and quarantine decisions. The NHLS HIV Molecular Laboratory in Johannesburg, South Africa, is one of the largest autom...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205292/ https://www.ncbi.nlm.nih.gov/pubmed/34139371 http://dx.doi.org/10.1016/j.ijid.2021.06.019 |
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author | Hans, Lucia Steegen, Kim Ketseoglou, Irene Mahlumba, Zukiswa Cassim, Naseem Wiggill, Tracey Venter, W.D. Francois Stevens, Wendy |
author_facet | Hans, Lucia Steegen, Kim Ketseoglou, Irene Mahlumba, Zukiswa Cassim, Naseem Wiggill, Tracey Venter, W.D. Francois Stevens, Wendy |
author_sort | Hans, Lucia |
collection | PubMed |
description | Africa’s readiness to respond to the SARS-COV-2 pandemic was tested due to reliance on rapid turn-around-time of polymerase chain reaction results for clinical management, isolation and quarantine decisions. The NHLS HIV Molecular Laboratory in Johannesburg, South Africa, is one of the largest automated HIV molecular laboratories worldwide. Despite its extensive molecular capacity and experience in managing high volumes acquired from a large HIV program, significant challenges were encountered during its rapid transition to large scale SARS-CoV-2 testing. We describe the strategies employed to manage these challenges that resulted in a 30% improvement in SARS-CoV-2 test turn-around-time during the first wave peak during which approximately 25000 samples were tested per month, and further improvement during the second wave peak, with 81% within targeted turn-around-time. |
format | Online Article Text |
id | pubmed-8205292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82052922021-06-16 Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory Hans, Lucia Steegen, Kim Ketseoglou, Irene Mahlumba, Zukiswa Cassim, Naseem Wiggill, Tracey Venter, W.D. Francois Stevens, Wendy Int J Infect Dis Short Communication Africa’s readiness to respond to the SARS-COV-2 pandemic was tested due to reliance on rapid turn-around-time of polymerase chain reaction results for clinical management, isolation and quarantine decisions. The NHLS HIV Molecular Laboratory in Johannesburg, South Africa, is one of the largest automated HIV molecular laboratories worldwide. Despite its extensive molecular capacity and experience in managing high volumes acquired from a large HIV program, significant challenges were encountered during its rapid transition to large scale SARS-CoV-2 testing. We describe the strategies employed to manage these challenges that resulted in a 30% improvement in SARS-CoV-2 test turn-around-time during the first wave peak during which approximately 25000 samples were tested per month, and further improvement during the second wave peak, with 81% within targeted turn-around-time. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-09 2021-06-15 /pmc/articles/PMC8205292/ /pubmed/34139371 http://dx.doi.org/10.1016/j.ijid.2021.06.019 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Short Communication Hans, Lucia Steegen, Kim Ketseoglou, Irene Mahlumba, Zukiswa Cassim, Naseem Wiggill, Tracey Venter, W.D. Francois Stevens, Wendy Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory |
title | Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory |
title_full | Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory |
title_fullStr | Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory |
title_full_unstemmed | Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory |
title_short | Preparing for the next pandemic: Lessons from rapid scale-up of SARS-CoV-2 testing in a South African high-throughput automated HIV molecular laboratory |
title_sort | preparing for the next pandemic: lessons from rapid scale-up of sars-cov-2 testing in a south african high-throughput automated hiv molecular laboratory |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205292/ https://www.ncbi.nlm.nih.gov/pubmed/34139371 http://dx.doi.org/10.1016/j.ijid.2021.06.019 |
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