miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation

MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary explo...

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Detalles Bibliográficos
Autores principales: Zhang, Yani, Zhang, Wenhui, Hu, Cai, Wang, Yingjie, Wang, Man, Zuo, Qisheng, Elsayed, Ahmed Kamel, Li, Yi, Li, Bichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205581/
https://www.ncbi.nlm.nih.gov/pubmed/34211555
http://dx.doi.org/10.1155/2021/5546936
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author Zhang, Yani
Zhang, Wenhui
Hu, Cai
Wang, Yingjie
Wang, Man
Zuo, Qisheng
Elsayed, Ahmed Kamel
Li, Yi
Li, Bichun
author_facet Zhang, Yani
Zhang, Wenhui
Hu, Cai
Wang, Yingjie
Wang, Man
Zuo, Qisheng
Elsayed, Ahmed Kamel
Li, Yi
Li, Bichun
author_sort Zhang, Yani
collection PubMed
description MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary exploration to determine the relationship among miR-302d, lncRNA-341(interacting with miR-302d), and target gene TLE4. The results showed that lncRNA-341 can competitively bind to miR-302d to decrease the targeted binding of miR-302d and TLE4 which promotes the differentiation of chicken SSCs. Moreover, it is suggested that miR-302d may participate in the Wnt signaling pathway through TLE4.
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spelling pubmed-82055812021-06-30 miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation Zhang, Yani Zhang, Wenhui Hu, Cai Wang, Yingjie Wang, Man Zuo, Qisheng Elsayed, Ahmed Kamel Li, Yi Li, Bichun Stem Cells Int Research Article MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary exploration to determine the relationship among miR-302d, lncRNA-341(interacting with miR-302d), and target gene TLE4. The results showed that lncRNA-341 can competitively bind to miR-302d to decrease the targeted binding of miR-302d and TLE4 which promotes the differentiation of chicken SSCs. Moreover, it is suggested that miR-302d may participate in the Wnt signaling pathway through TLE4. Hindawi 2021-06-08 /pmc/articles/PMC8205581/ /pubmed/34211555 http://dx.doi.org/10.1155/2021/5546936 Text en Copyright © 2021 Yani Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Yani
Zhang, Wenhui
Hu, Cai
Wang, Yingjie
Wang, Man
Zuo, Qisheng
Elsayed, Ahmed Kamel
Li, Yi
Li, Bichun
miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation
title miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation
title_full miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation
title_fullStr miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation
title_full_unstemmed miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation
title_short miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation
title_sort mir-302d competitively binding with the lncrna-341 targets tle4 in the process of ssc generation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205581/
https://www.ncbi.nlm.nih.gov/pubmed/34211555
http://dx.doi.org/10.1155/2021/5546936
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