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Mechanisms and cell lineages in lymphatic vascular development
Lymphatic vessels have critical roles in both health and disease and their study is a rapidly evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in the developing embryo has recently shifted. Originally, they were thought to solely derive by sprouting from vein...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205918/ https://www.ncbi.nlm.nih.gov/pubmed/33825109 http://dx.doi.org/10.1007/s10456-021-09784-8 |
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author | Jafree, Daniyal J. Long, David A. Scambler, Peter J. Ruhrberg, Christiana |
author_facet | Jafree, Daniyal J. Long, David A. Scambler, Peter J. Ruhrberg, Christiana |
author_sort | Jafree, Daniyal J. |
collection | PubMed |
description | Lymphatic vessels have critical roles in both health and disease and their study is a rapidly evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in the developing embryo has recently shifted. Originally, they were thought to solely derive by sprouting from veins. Since then, several studies have uncovered novel cellular mechanisms and a diversity of contributing cell lineages in the formation of organ lymphatic vasculature. Here, we review the key mechanisms and cell lineages contributing to lymphatic development, discuss the advantages and limitations of experimental techniques used for their study and highlight remaining knowledge gaps that require urgent attention. Emerging technologies should accelerate our understanding of how lymphatic vessels develop normally and how they contribute to disease. |
format | Online Article Text |
id | pubmed-8205918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-82059182021-07-01 Mechanisms and cell lineages in lymphatic vascular development Jafree, Daniyal J. Long, David A. Scambler, Peter J. Ruhrberg, Christiana Angiogenesis Review Paper Lymphatic vessels have critical roles in both health and disease and their study is a rapidly evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in the developing embryo has recently shifted. Originally, they were thought to solely derive by sprouting from veins. Since then, several studies have uncovered novel cellular mechanisms and a diversity of contributing cell lineages in the formation of organ lymphatic vasculature. Here, we review the key mechanisms and cell lineages contributing to lymphatic development, discuss the advantages and limitations of experimental techniques used for their study and highlight remaining knowledge gaps that require urgent attention. Emerging technologies should accelerate our understanding of how lymphatic vessels develop normally and how they contribute to disease. Springer Netherlands 2021-04-06 2021 /pmc/articles/PMC8205918/ /pubmed/33825109 http://dx.doi.org/10.1007/s10456-021-09784-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Paper Jafree, Daniyal J. Long, David A. Scambler, Peter J. Ruhrberg, Christiana Mechanisms and cell lineages in lymphatic vascular development |
title | Mechanisms and cell lineages in lymphatic vascular development |
title_full | Mechanisms and cell lineages in lymphatic vascular development |
title_fullStr | Mechanisms and cell lineages in lymphatic vascular development |
title_full_unstemmed | Mechanisms and cell lineages in lymphatic vascular development |
title_short | Mechanisms and cell lineages in lymphatic vascular development |
title_sort | mechanisms and cell lineages in lymphatic vascular development |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205918/ https://www.ncbi.nlm.nih.gov/pubmed/33825109 http://dx.doi.org/10.1007/s10456-021-09784-8 |
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