USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α

Although endocrine therapies targeting estrogen receptor α (ERα) are effective in managing ER positive (+) breast cancer, many patients have primary resistance or develop resistance to endocrine therapies. In addition, ER+ breast cancer with PIK3CA activating mutations and 11q13-14 amplification hav...

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Detalles Bibliográficos
Autores principales: Cao, Jiawei, Wu, Du, Wu, Guang, Wang, Yaqi, Ren, Tianhao, Wang, Yang, Lv, Yingshuai, Sun, Wei, Wang, Jieyi, Qian, Changrui, He, Licai, Yang, Kaiyan, Li, Hongzhi, Gu, Haihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206120/
https://www.ncbi.nlm.nih.gov/pubmed/34131114
http://dx.doi.org/10.1038/s41419-021-03904-4

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