A genetic polymorphism in P2RY(1) impacts response to clopidogrel in cats with hypertrophic cardiomyopathy

Clopidogrel is converted to its active metabolite by cytochrome P450 isoenzymes and irreversibly inhibits platelet activation by antagonizing the adenosine-diphosphate (ADP) receptor. It is frequently used in cats with hypertrophic cardiomyopathy (HCM) to prevent thromboembolic complications. Howeve...

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Detalles Bibliográficos
Autores principales: Ueda, Yu, Li, Ronald H. L., Nguyen, Nghi, Ontiveros, Eric S., Kovacs, Samantha L., Oldach, Maureen S., Vernau, Karen M., Court, Michael H., Stern, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206363/
https://www.ncbi.nlm.nih.gov/pubmed/34131167
http://dx.doi.org/10.1038/s41598-021-91372-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206363/
https://www.ncbi.nlm.nih.gov/pubmed/34131167
http://dx.doi.org/10.1038/s41598-021-91372-3

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