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EPISPOT: An epigenome-driven approach for detecting and interpreting hotspots in molecular QTL studies

We present EPISPOT, a fully joint framework which exploits large panels of epigenetic annotations as variant-level information to enhance molecular quantitative trait locus (QTL) mapping. Thanks to a purpose-built Bayesian inferential algorithm, EPISPOT accommodates functional information for both c...

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Detalles Bibliográficos
Autores principales:	Ruffieux, Hélène, Fairfax, Benjamin P., Nassiri, Isar, Vigorito, Elena, Wallace, Chris, Richardson, Sylvia, Bottolo, Leonardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206410/ https://www.ncbi.nlm.nih.gov/pubmed/33909991 http://dx.doi.org/10.1016/j.ajhg.2021.04.010

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