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Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications

Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6-guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part of the first-line treatment of high-grade gliomas. The main advantages are its high oral bioavailability...

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Detalles Bibliográficos
Autores principales:	Ortiz, Raúl, Perazzoli, Gloria, Cabeza, Laura, Jiménez-Luna, Cristina, Luque, Raquel, Prados, Jose, Melguizo, Consolación
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206461/ https://www.ncbi.nlm.nih.gov/pubmed/32589560 http://dx.doi.org/10.2174/1570159X18666200626204005

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