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Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases

Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce...

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Autores principales: Jazayeri, Seyed Davoud, Lim, Hui Xuan, Shameli, Kamyar, Yeap, Swee Keong, Poh, Chit Laa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206556/
https://www.ncbi.nlm.nih.gov/pubmed/34149426
http://dx.doi.org/10.3389/fphar.2021.682286
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author Jazayeri, Seyed Davoud
Lim, Hui Xuan
Shameli, Kamyar
Yeap, Swee Keong
Poh, Chit Laa
author_facet Jazayeri, Seyed Davoud
Lim, Hui Xuan
Shameli, Kamyar
Yeap, Swee Keong
Poh, Chit Laa
author_sort Jazayeri, Seyed Davoud
collection PubMed
description Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce broad-spectrum and long-lasting immunity. Therefore, to design a successful vaccine, it is essential to stimulate the mucosal as well as systemic immune responses. Successful oral vaccines need to overcome the harsh gastrointestinal environment such as the extremely low pH, proteolytic enzymes, bile salts as well as low permeability and the low immunogenicity of vaccines. In recent years, several delivery systems and adjuvants have been developed for improving oral vaccine delivery and immunogenicity. Formulation of vaccines with nanoparticles and microparticles have been shown to improve antigen stability, availability and adjuvanticity as well as immunostimulatory capacity, target delivery and specific release. This review discusses how nanoparticles (NPs) and microparticles (MPs) as oral carriers with adjuvant characteristics can be beneficial in oral vaccine development.
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spelling pubmed-82065562021-06-17 Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases Jazayeri, Seyed Davoud Lim, Hui Xuan Shameli, Kamyar Yeap, Swee Keong Poh, Chit Laa Front Pharmacol Pharmacology Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce broad-spectrum and long-lasting immunity. Therefore, to design a successful vaccine, it is essential to stimulate the mucosal as well as systemic immune responses. Successful oral vaccines need to overcome the harsh gastrointestinal environment such as the extremely low pH, proteolytic enzymes, bile salts as well as low permeability and the low immunogenicity of vaccines. In recent years, several delivery systems and adjuvants have been developed for improving oral vaccine delivery and immunogenicity. Formulation of vaccines with nanoparticles and microparticles have been shown to improve antigen stability, availability and adjuvanticity as well as immunostimulatory capacity, target delivery and specific release. This review discusses how nanoparticles (NPs) and microparticles (MPs) as oral carriers with adjuvant characteristics can be beneficial in oral vaccine development. Frontiers Media S.A. 2021-06-02 /pmc/articles/PMC8206556/ /pubmed/34149426 http://dx.doi.org/10.3389/fphar.2021.682286 Text en Copyright © 2021 Jazayeri, Lim, Shameli, Yeap and Poh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jazayeri, Seyed Davoud
Lim, Hui Xuan
Shameli, Kamyar
Yeap, Swee Keong
Poh, Chit Laa
Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases
title Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases
title_full Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases
title_fullStr Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases
title_full_unstemmed Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases
title_short Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases
title_sort nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206556/
https://www.ncbi.nlm.nih.gov/pubmed/34149426
http://dx.doi.org/10.3389/fphar.2021.682286
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