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COVID-19 and Candida duobushaemulonii superinfection: A case report

INTRODUCTION: Critically ill COVID-19 patients are at high risk for nosocomial bacterial and fungal infections due to several predisposing factors such as intensive care unit stay, mechanical ventilation, and broad-spectrum antibiotics. Data regarding multidrug resistant (MDR) Candida species in COV...

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Autores principales: Awada, Bassem, Alam, Walid, Chalfoun, Maria, Araj, George, Bizri, Abdul Rahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SFMM. Published by Elsevier Masson SAS. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206624/
https://www.ncbi.nlm.nih.gov/pubmed/34186378
http://dx.doi.org/10.1016/j.mycmed.2021.101168
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author Awada, Bassem
Alam, Walid
Chalfoun, Maria
Araj, George
Bizri, Abdul Rahman
author_facet Awada, Bassem
Alam, Walid
Chalfoun, Maria
Araj, George
Bizri, Abdul Rahman
author_sort Awada, Bassem
collection PubMed
description INTRODUCTION: Critically ill COVID-19 patients are at high risk for nosocomial bacterial and fungal infections due to several predisposing factors such as intensive care unit stay, mechanical ventilation, and broad-spectrum antibiotics. Data regarding multidrug resistant (MDR) Candida species in COVID-19 patients is scarce, and nonexistent regarding Candida duobushaemulonii superinfections. CASE DESCRIPTION: A 34-year-old male presented to our institution with acute respiratory distress syndrome (ARDS) due to COVID-19 infection and developed Candida duobushaemulonii fungemia after multiple courses of antibiotics and prolonged mechanical ventilation. He died after recurrent pneumothorax led to respiratory failure and cardiac arrest. DISCUSSION: Bacterial and fungal infections are common complications of viral pneumonia in critically ill patients. Data regarding these infections in COVID-19 patients has been poorly studied with only a few cases reporting secondary infection, mostly without identifying specific pathogens. Prolonged hospital stays, invasive interventions (central venous catheter, mechanical ventilation), and the use of broad-spectrum antibiotics in COVID-19 infections could carry a high risk of bacterial and/or fungal superinfections. CONCLUSION: Strategies to improve outcome in COVID-19 ICU patients should include early recognition of candidemia and appropriate antifungal therapy.
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spelling pubmed-82066242021-06-16 COVID-19 and Candida duobushaemulonii superinfection: A case report Awada, Bassem Alam, Walid Chalfoun, Maria Araj, George Bizri, Abdul Rahman J Mycol Med Case Report INTRODUCTION: Critically ill COVID-19 patients are at high risk for nosocomial bacterial and fungal infections due to several predisposing factors such as intensive care unit stay, mechanical ventilation, and broad-spectrum antibiotics. Data regarding multidrug resistant (MDR) Candida species in COVID-19 patients is scarce, and nonexistent regarding Candida duobushaemulonii superinfections. CASE DESCRIPTION: A 34-year-old male presented to our institution with acute respiratory distress syndrome (ARDS) due to COVID-19 infection and developed Candida duobushaemulonii fungemia after multiple courses of antibiotics and prolonged mechanical ventilation. He died after recurrent pneumothorax led to respiratory failure and cardiac arrest. DISCUSSION: Bacterial and fungal infections are common complications of viral pneumonia in critically ill patients. Data regarding these infections in COVID-19 patients has been poorly studied with only a few cases reporting secondary infection, mostly without identifying specific pathogens. Prolonged hospital stays, invasive interventions (central venous catheter, mechanical ventilation), and the use of broad-spectrum antibiotics in COVID-19 infections could carry a high risk of bacterial and/or fungal superinfections. CONCLUSION: Strategies to improve outcome in COVID-19 ICU patients should include early recognition of candidemia and appropriate antifungal therapy. SFMM. Published by Elsevier Masson SAS. 2021-09 2021-06-16 /pmc/articles/PMC8206624/ /pubmed/34186378 http://dx.doi.org/10.1016/j.mycmed.2021.101168 Text en © 2021 SFMM. Published by Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Awada, Bassem
Alam, Walid
Chalfoun, Maria
Araj, George
Bizri, Abdul Rahman
COVID-19 and Candida duobushaemulonii superinfection: A case report
title COVID-19 and Candida duobushaemulonii superinfection: A case report
title_full COVID-19 and Candida duobushaemulonii superinfection: A case report
title_fullStr COVID-19 and Candida duobushaemulonii superinfection: A case report
title_full_unstemmed COVID-19 and Candida duobushaemulonii superinfection: A case report
title_short COVID-19 and Candida duobushaemulonii superinfection: A case report
title_sort covid-19 and candida duobushaemulonii superinfection: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206624/
https://www.ncbi.nlm.nih.gov/pubmed/34186378
http://dx.doi.org/10.1016/j.mycmed.2021.101168
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