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Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel
Twenty different batches of gels containing metaxalone and diclofenac potassium were prepared for topical application. These drugs act synergistically in the management of pain and inflammation. Gels were prepared by varying the type of gelling agent (ten batches each of hydroxyl propyl methyl cellu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Environmental Health and Toxicology/Korea Society for Environmental Analysis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207004/ https://www.ncbi.nlm.nih.gov/pubmed/33499562 http://dx.doi.org/10.5620/eaht.2021001 |
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author | Tiwari, Ashutosh Bag, Puja Sarkar, Mrinmoy Chawla, Viney Chawla, Pooja A. |
author_facet | Tiwari, Ashutosh Bag, Puja Sarkar, Mrinmoy Chawla, Viney Chawla, Pooja A. |
author_sort | Tiwari, Ashutosh |
collection | PubMed |
description | Twenty different batches of gels containing metaxalone and diclofenac potassium were prepared for topical application. These drugs act synergistically in the management of pain and inflammation. Gels were prepared by varying the type of gelling agent (ten batches each of hydroxyl propyl methyl cellulose and carbopol 934). The prepared gels were characterized and evaluated. Batch F7 emerged as the best batch on the basis of favourable pH, high drug content, homogeneity and drug release. HPLC (High-performance liquid chromatography) method validation of gel formulation was also carried out and the developed and validated method was found to be robust and accurate. |
format | Online Article Text |
id | pubmed-8207004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society of Environmental Health and Toxicology/Korea Society for Environmental Analysis |
record_format | MEDLINE/PubMed |
spelling | pubmed-82070042021-06-28 Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel Tiwari, Ashutosh Bag, Puja Sarkar, Mrinmoy Chawla, Viney Chawla, Pooja A. Environ Anal Health Toxicol Original Article Twenty different batches of gels containing metaxalone and diclofenac potassium were prepared for topical application. These drugs act synergistically in the management of pain and inflammation. Gels were prepared by varying the type of gelling agent (ten batches each of hydroxyl propyl methyl cellulose and carbopol 934). The prepared gels were characterized and evaluated. Batch F7 emerged as the best batch on the basis of favourable pH, high drug content, homogeneity and drug release. HPLC (High-performance liquid chromatography) method validation of gel formulation was also carried out and the developed and validated method was found to be robust and accurate. Korean Society of Environmental Health and Toxicology/Korea Society for Environmental Analysis 2021-01-11 /pmc/articles/PMC8207004/ /pubmed/33499562 http://dx.doi.org/10.5620/eaht.2021001 Text en Copyright © 2021 The Korean Society of Environmental Health and Toxicology/Korea Society for Environmental Analysis https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Tiwari, Ashutosh Bag, Puja Sarkar, Mrinmoy Chawla, Viney Chawla, Pooja A. Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel |
title | Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel |
title_full | Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel |
title_fullStr | Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel |
title_full_unstemmed | Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel |
title_short | Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel |
title_sort | formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207004/ https://www.ncbi.nlm.nih.gov/pubmed/33499562 http://dx.doi.org/10.5620/eaht.2021001 |
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