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Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1(G93A) murine model of amyotrophic lateral sclerosis in a sex-dependent manner

BACKGROUND: Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The receptor for advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate in the diseased spinal cord an...

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Detalles Bibliográficos
Autores principales:	MacLean, Michael, Juranek, Judyta, Cuddapah, Swetha, López-Díez, Raquel, Ruiz, Henry H., Hu, Jiyuan, Frye, Laura, Li, Huilin, Gugger, Paul F., Schmidt, Ann Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207569/ https://www.ncbi.nlm.nih.gov/pubmed/34130712 http://dx.doi.org/10.1186/s12974-021-02191-2

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