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Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila

BACKGROUND: The anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila. Unlike known monoterpene indole alkaloids, CPT in C. acuminata is biosynthesized via the key intermediate strictosidinic acid,...

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Detalles Bibliográficos
Autores principales:	Yang, Mengquan, Wang, Qiang, Liu, Yining, Hao, Xiaolong, Wang, Can, Liang, Yuchen, Chen, Jianbo, Xiao, Youli, Kai, Guoyin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207662/ https://www.ncbi.nlm.nih.gov/pubmed/34134716 http://dx.doi.org/10.1186/s12915-021-01051-y

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