Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis

BACKGROUND: Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity IgE Fc receptor (FcεRI) binding. This study examined c-Fos involvement in MC act...

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Detalles Bibliográficos
Autores principales: Wang, Hui-Na, Ji, Kunmei, Zhang, Li-Na, Xie, Chu-Chu, Li, Wei-Yong, Zhao, Zhen-Fu, Chen, Jia-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207675/
https://www.ncbi.nlm.nih.gov/pubmed/34130714
http://dx.doi.org/10.1186/s12967-021-02932-0

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