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A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis

BACKGROUND: SARS‐CoV2 has affected more than 73.8 million individuals. While SARS‐CoV2 is considered a predominantly respiratory virus, we report a trend of bradycardia among hospitalized patients, particularly in association with mortality. METHODOLOGY: The multi‐center retrospective analysis consi...

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Autores principales: Kumar, Sabina, Arcuri, Christina, Chaudhuri, Sumanta, Gupta, Rahul, Aseri, Mahendra, Barve, Pranav, Shah, Shivang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207973/
https://www.ncbi.nlm.nih.gov/pubmed/33964035
http://dx.doi.org/10.1002/clc.23622
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author Kumar, Sabina
Arcuri, Christina
Chaudhuri, Sumanta
Gupta, Rahul
Aseri, Mahendra
Barve, Pranav
Shah, Shivang
author_facet Kumar, Sabina
Arcuri, Christina
Chaudhuri, Sumanta
Gupta, Rahul
Aseri, Mahendra
Barve, Pranav
Shah, Shivang
author_sort Kumar, Sabina
collection PubMed
description BACKGROUND: SARS‐CoV2 has affected more than 73.8 million individuals. While SARS‐CoV2 is considered a predominantly respiratory virus, we report a trend of bradycardia among hospitalized patients, particularly in association with mortality. METHODOLOGY: The multi‐center retrospective analysis consisted of 1053 COVID‐19 positive patients from March to August 2020. A trend of bradycardia was noted in the study population. Absolute bradycardia and profound bradycardia was defined as a sustained heart rate < 60 BPM and < 50 BPM, respectively, on two separate occasions, a minimum of 4 h apart during hospitalization. Each bradycardic event was confirmed by two physicians and exclusion criteria included: less than 18 years old, end of life bradycardia, left AMA, or taking AV Nodal blockers. Data was fetched using a SQL program through the EMR and data was analyzed using SPSS 27.0. A logistic regression was done to study the effect of bradycardia, age, gender, and BMI on mortality in the study group. RESULTS: 24.9% patients had absolute bradycardia while 13.0% had profound bradycardia. Patients with absolute bradycardia had an odds ratio of 6.59 (95% CI [2.83–15.36]) for mortality compared with individuals with a normal HR response. The logistic regression model explained 19.6% (Nagelkerke R(2)) of variance in the mortality, correctly classified 88.6% of cases, and was statistically significant X(2) (5)=47.10, p < .001. For each year of age > 18, the odds of dying increased 1.048 times (95% CI [1.25–5.27]). CONCLUSION: The incidence of absolute bradycardia was found in 24.9% of the study cohort and these individuals were found to have a significant increase in mortality.
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spelling pubmed-82079732021-06-25 A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis Kumar, Sabina Arcuri, Christina Chaudhuri, Sumanta Gupta, Rahul Aseri, Mahendra Barve, Pranav Shah, Shivang Clin Cardiol Clinical Investigations BACKGROUND: SARS‐CoV2 has affected more than 73.8 million individuals. While SARS‐CoV2 is considered a predominantly respiratory virus, we report a trend of bradycardia among hospitalized patients, particularly in association with mortality. METHODOLOGY: The multi‐center retrospective analysis consisted of 1053 COVID‐19 positive patients from March to August 2020. A trend of bradycardia was noted in the study population. Absolute bradycardia and profound bradycardia was defined as a sustained heart rate < 60 BPM and < 50 BPM, respectively, on two separate occasions, a minimum of 4 h apart during hospitalization. Each bradycardic event was confirmed by two physicians and exclusion criteria included: less than 18 years old, end of life bradycardia, left AMA, or taking AV Nodal blockers. Data was fetched using a SQL program through the EMR and data was analyzed using SPSS 27.0. A logistic regression was done to study the effect of bradycardia, age, gender, and BMI on mortality in the study group. RESULTS: 24.9% patients had absolute bradycardia while 13.0% had profound bradycardia. Patients with absolute bradycardia had an odds ratio of 6.59 (95% CI [2.83–15.36]) for mortality compared with individuals with a normal HR response. The logistic regression model explained 19.6% (Nagelkerke R(2)) of variance in the mortality, correctly classified 88.6% of cases, and was statistically significant X(2) (5)=47.10, p < .001. For each year of age > 18, the odds of dying increased 1.048 times (95% CI [1.25–5.27]). CONCLUSION: The incidence of absolute bradycardia was found in 24.9% of the study cohort and these individuals were found to have a significant increase in mortality. Wiley Periodicals, Inc. 2021-05-08 /pmc/articles/PMC8207973/ /pubmed/33964035 http://dx.doi.org/10.1002/clc.23622 Text en © 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigations
Kumar, Sabina
Arcuri, Christina
Chaudhuri, Sumanta
Gupta, Rahul
Aseri, Mahendra
Barve, Pranav
Shah, Shivang
A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis
title A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis
title_full A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis
title_fullStr A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis
title_full_unstemmed A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis
title_short A novel study on SARS‐COV‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis
title_sort novel study on sars‐cov‐2 virus associated bradycardia as a predictor of mortality‐retrospective multicenter analysis
topic Clinical Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207973/
https://www.ncbi.nlm.nih.gov/pubmed/33964035
http://dx.doi.org/10.1002/clc.23622
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