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The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study

BACKGROUND: Premature ventricular contractions (PVCs) may increase during pregnancy, however, few studies have evaluated the relationship between PVCs and the pregnant outcomes. HYPOTHESIS: PVCs may increase the adverse fetal/neonatal outcomes in pregnant women. METHODS: Six thousand one hundred and...

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Autores principales: Lin, Jing, Qian, Yanxia, Chen, Qiushi, Zhang, Mingming, Chen, Yaoxi, Xu, Ruijie, Chen, Jingxian, Shi, Yukang, Yang, Shunxin, Luo, Xinyi, Ding, Qiang, Wu, Xin, Wang, Junhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207974/
https://www.ncbi.nlm.nih.gov/pubmed/33955019
http://dx.doi.org/10.1002/clc.23612
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author Lin, Jing
Qian, Yanxia
Chen, Qiushi
Zhang, Mingming
Chen, Yaoxi
Xu, Ruijie
Chen, Jingxian
Shi, Yukang
Yang, Shunxin
Luo, Xinyi
Ding, Qiang
Wu, Xin
Wang, Junhong
author_facet Lin, Jing
Qian, Yanxia
Chen, Qiushi
Zhang, Mingming
Chen, Yaoxi
Xu, Ruijie
Chen, Jingxian
Shi, Yukang
Yang, Shunxin
Luo, Xinyi
Ding, Qiang
Wu, Xin
Wang, Junhong
author_sort Lin, Jing
collection PubMed
description BACKGROUND: Premature ventricular contractions (PVCs) may increase during pregnancy, however, few studies have evaluated the relationship between PVCs and the pregnant outcomes. HYPOTHESIS: PVCs may increase the adverse fetal/neonatal outcomes in pregnant women. METHODS: Six thousand one hundred and forty‐eight pregnant women were prospectively enrolled in our center between 2017 and 2019 in the study. The average PVC burden was determined by calculating the number of PVCs in total beats. Those who had a PVC burden >0.5% were divided into two groups based on the presence or absence of adverse fetal or neonatal events. The adverse outcomes were compared between the groups to assess the impact of PVCs on pregnancy. RESULTS: A total of 103 (1.68%) women with a PVC burden >0.5% were recorded. Among them, 17 adverse events (12 cases) were documented, which was significantly higher than that among women without PVCs (11.65% vs. 2.93%, p < .01). The median PVC burden among pregnant women with PVCs was 2.84% (1.02%–6.1%). Furthermore, compared with that of the women without adverse events, the median PVC burden of women with adverse fetal or neonatal outcomes was significantly higher (9.02% vs. 2.30%, p < .01). Multivariate logistic regression analysis demonstrated that not the LVEF, heart rate and bigeminy, but only the PVC burden was associated with adverse fetal or neonatal outcomes among pregnant women with PVCs (OR: 1.34, 95% CI [1.11–1.61], p < .01). CONCLUSIONS: Frequent PVCs have adverse effects on pregnancy, and the PVC burden might be an important factor associated with adverse fetal and neonatal outcomes among pregnant women with PVCs.
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spelling pubmed-82079742021-06-25 The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study Lin, Jing Qian, Yanxia Chen, Qiushi Zhang, Mingming Chen, Yaoxi Xu, Ruijie Chen, Jingxian Shi, Yukang Yang, Shunxin Luo, Xinyi Ding, Qiang Wu, Xin Wang, Junhong Clin Cardiol Clinical Investigations BACKGROUND: Premature ventricular contractions (PVCs) may increase during pregnancy, however, few studies have evaluated the relationship between PVCs and the pregnant outcomes. HYPOTHESIS: PVCs may increase the adverse fetal/neonatal outcomes in pregnant women. METHODS: Six thousand one hundred and forty‐eight pregnant women were prospectively enrolled in our center between 2017 and 2019 in the study. The average PVC burden was determined by calculating the number of PVCs in total beats. Those who had a PVC burden >0.5% were divided into two groups based on the presence or absence of adverse fetal or neonatal events. The adverse outcomes were compared between the groups to assess the impact of PVCs on pregnancy. RESULTS: A total of 103 (1.68%) women with a PVC burden >0.5% were recorded. Among them, 17 adverse events (12 cases) were documented, which was significantly higher than that among women without PVCs (11.65% vs. 2.93%, p < .01). The median PVC burden among pregnant women with PVCs was 2.84% (1.02%–6.1%). Furthermore, compared with that of the women without adverse events, the median PVC burden of women with adverse fetal or neonatal outcomes was significantly higher (9.02% vs. 2.30%, p < .01). Multivariate logistic regression analysis demonstrated that not the LVEF, heart rate and bigeminy, but only the PVC burden was associated with adverse fetal or neonatal outcomes among pregnant women with PVCs (OR: 1.34, 95% CI [1.11–1.61], p < .01). CONCLUSIONS: Frequent PVCs have adverse effects on pregnancy, and the PVC burden might be an important factor associated with adverse fetal and neonatal outcomes among pregnant women with PVCs. Wiley Periodicals, Inc. 2021-05-06 /pmc/articles/PMC8207974/ /pubmed/33955019 http://dx.doi.org/10.1002/clc.23612 Text en © 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigations
Lin, Jing
Qian, Yanxia
Chen, Qiushi
Zhang, Mingming
Chen, Yaoxi
Xu, Ruijie
Chen, Jingxian
Shi, Yukang
Yang, Shunxin
Luo, Xinyi
Ding, Qiang
Wu, Xin
Wang, Junhong
The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study
title The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study
title_full The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study
title_fullStr The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study
title_full_unstemmed The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study
title_short The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study
title_sort burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: a prospective cohort study
topic Clinical Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207974/
https://www.ncbi.nlm.nih.gov/pubmed/33955019
http://dx.doi.org/10.1002/clc.23612
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