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Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears

The intra-articular synovial fluid environment in skeletally immature patients following an ACL tear is complex and remains undefined. Levels of inflammatory and anti-inflammatory cytokines change significantly in response to trauma and collectively define the inflammatory environment. Of these fact...

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Autores principales: Turati, Marco, Franchi, Silvia, Leone, Giulio, Piatti, Massimiliano, Zanchi, Nicolò, Gandolla, Marta, Rigamonti, Luca, Sacerdote, Paola, Rizzi, Laura, Pedrocchi, Alessandra, Omeljaniuk, Robert J., Zatti, Giovanni, Torsello, Antonio, Bigoni, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208028/
https://www.ncbi.nlm.nih.gov/pubmed/34150787
http://dx.doi.org/10.3389/fmed.2021.610866
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author Turati, Marco
Franchi, Silvia
Leone, Giulio
Piatti, Massimiliano
Zanchi, Nicolò
Gandolla, Marta
Rigamonti, Luca
Sacerdote, Paola
Rizzi, Laura
Pedrocchi, Alessandra
Omeljaniuk, Robert J.
Zatti, Giovanni
Torsello, Antonio
Bigoni, Marco
author_facet Turati, Marco
Franchi, Silvia
Leone, Giulio
Piatti, Massimiliano
Zanchi, Nicolò
Gandolla, Marta
Rigamonti, Luca
Sacerdote, Paola
Rizzi, Laura
Pedrocchi, Alessandra
Omeljaniuk, Robert J.
Zatti, Giovanni
Torsello, Antonio
Bigoni, Marco
author_sort Turati, Marco
collection PubMed
description The intra-articular synovial fluid environment in skeletally immature patients following an ACL tear is complex and remains undefined. Levels of inflammatory and anti-inflammatory cytokines change significantly in response to trauma and collectively define the inflammatory environment. Of these factors the resolvins, with their inherent anti-inflammatory, reparative, and analgesic properties, have become prominent. This study examined the levels of resolvins and other cytokines after ACL tears in skeletally immature and adult patients in order to determine if skeletal maturity affects the inflammatory pattern. Skeletally immature and adult patients with an anterior cruciate ligament injury and meniscal tears were prospectively enrolled over a 5-month period. Synovial fluid samples were obtained before surgery quantifying Resolvin E1, IL-1β, TNF-α, and IL-10 by ELISA. Comparisons between skeletally immature patients and adults, the influence of meniscal tear, growth plate maturity and time from trauma were analyzed. Skeletally immature patients had significantly greater levels of Resolvin E1 and IL-10 compared with adults with an isolated anterior cruciate ligament lesion. Among the injured skeletally immature patients Resolvin E1 levels were greater in the open growth plate group compared with those with closing growth plates. Moreover, levels of Resolvin E1 and IL-10 appeared to decrease with time. Our results suggest that skeletally immature patients have a stronger activation of the Resolvin pattern compared to adult patients and that synovial fluid Resolvins could play an antinflammatory role in the knee after anterior cruciate ligament lesion and that its activity may be synergistic with that of IL-10.
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spelling pubmed-82080282021-06-17 Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears Turati, Marco Franchi, Silvia Leone, Giulio Piatti, Massimiliano Zanchi, Nicolò Gandolla, Marta Rigamonti, Luca Sacerdote, Paola Rizzi, Laura Pedrocchi, Alessandra Omeljaniuk, Robert J. Zatti, Giovanni Torsello, Antonio Bigoni, Marco Front Med (Lausanne) Medicine The intra-articular synovial fluid environment in skeletally immature patients following an ACL tear is complex and remains undefined. Levels of inflammatory and anti-inflammatory cytokines change significantly in response to trauma and collectively define the inflammatory environment. Of these factors the resolvins, with their inherent anti-inflammatory, reparative, and analgesic properties, have become prominent. This study examined the levels of resolvins and other cytokines after ACL tears in skeletally immature and adult patients in order to determine if skeletal maturity affects the inflammatory pattern. Skeletally immature and adult patients with an anterior cruciate ligament injury and meniscal tears were prospectively enrolled over a 5-month period. Synovial fluid samples were obtained before surgery quantifying Resolvin E1, IL-1β, TNF-α, and IL-10 by ELISA. Comparisons between skeletally immature patients and adults, the influence of meniscal tear, growth plate maturity and time from trauma were analyzed. Skeletally immature patients had significantly greater levels of Resolvin E1 and IL-10 compared with adults with an isolated anterior cruciate ligament lesion. Among the injured skeletally immature patients Resolvin E1 levels were greater in the open growth plate group compared with those with closing growth plates. Moreover, levels of Resolvin E1 and IL-10 appeared to decrease with time. Our results suggest that skeletally immature patients have a stronger activation of the Resolvin pattern compared to adult patients and that synovial fluid Resolvins could play an antinflammatory role in the knee after anterior cruciate ligament lesion and that its activity may be synergistic with that of IL-10. Frontiers Media S.A. 2021-06-02 /pmc/articles/PMC8208028/ /pubmed/34150787 http://dx.doi.org/10.3389/fmed.2021.610866 Text en Copyright © 2021 Turati, Franchi, Leone, Piatti, Zanchi, Gandolla, Rigamonti, Sacerdote, Rizzi, Pedrocchi, Omeljaniuk, Zatti, Torsello and Bigoni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Turati, Marco
Franchi, Silvia
Leone, Giulio
Piatti, Massimiliano
Zanchi, Nicolò
Gandolla, Marta
Rigamonti, Luca
Sacerdote, Paola
Rizzi, Laura
Pedrocchi, Alessandra
Omeljaniuk, Robert J.
Zatti, Giovanni
Torsello, Antonio
Bigoni, Marco
Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears
title Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears
title_full Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears
title_fullStr Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears
title_full_unstemmed Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears
title_short Resolvin E1 and Cytokines Environment in Skeletally Immature and Adult ACL Tears
title_sort resolvin e1 and cytokines environment in skeletally immature and adult acl tears
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208028/
https://www.ncbi.nlm.nih.gov/pubmed/34150787
http://dx.doi.org/10.3389/fmed.2021.610866
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