Cargando…
Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells
Histone deacetylase inhibitors (HDACIs) are antitumor drugs that are being developed for use in clinical settings. HDACIs enhance histone or nonhistone acetylation and promote gene transcription via epigenetic regulation. Importantly, these drugs have cytotoxic or cytostatic properties and can direc...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208029/ https://www.ncbi.nlm.nih.gov/pubmed/34149732 http://dx.doi.org/10.3389/fimmu.2021.690207 |
_version_ | 1783708873269444608 |
---|---|
author | Cui, Yudan Cai, Jingshan Wang, Wenxin Wang, Shengjun |
author_facet | Cui, Yudan Cai, Jingshan Wang, Wenxin Wang, Shengjun |
author_sort | Cui, Yudan |
collection | PubMed |
description | Histone deacetylase inhibitors (HDACIs) are antitumor drugs that are being developed for use in clinical settings. HDACIs enhance histone or nonhistone acetylation and promote gene transcription via epigenetic regulation. Importantly, these drugs have cytotoxic or cytostatic properties and can directly inhibit tumor cells. However, how HDACIs regulate immunocytes in the tumor microenvironment, such as myeloid-derived suppressor cells (MDSCs), has yet to be elucidated. In this review, we summarize the effects of different HDACIs on the immunosuppressive function and expansion of MDSCs based on the findings of relevant studies. |
format | Online Article Text |
id | pubmed-8208029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82080292021-06-17 Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells Cui, Yudan Cai, Jingshan Wang, Wenxin Wang, Shengjun Front Immunol Immunology Histone deacetylase inhibitors (HDACIs) are antitumor drugs that are being developed for use in clinical settings. HDACIs enhance histone or nonhistone acetylation and promote gene transcription via epigenetic regulation. Importantly, these drugs have cytotoxic or cytostatic properties and can directly inhibit tumor cells. However, how HDACIs regulate immunocytes in the tumor microenvironment, such as myeloid-derived suppressor cells (MDSCs), has yet to be elucidated. In this review, we summarize the effects of different HDACIs on the immunosuppressive function and expansion of MDSCs based on the findings of relevant studies. Frontiers Media S.A. 2021-06-02 /pmc/articles/PMC8208029/ /pubmed/34149732 http://dx.doi.org/10.3389/fimmu.2021.690207 Text en Copyright © 2021 Cui, Cai, Wang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Cui, Yudan Cai, Jingshan Wang, Wenxin Wang, Shengjun Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells |
title | Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells |
title_full | Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells |
title_fullStr | Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells |
title_full_unstemmed | Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells |
title_short | Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells |
title_sort | regulatory effects of histone deacetylase inhibitors on myeloid-derived suppressor cells |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208029/ https://www.ncbi.nlm.nih.gov/pubmed/34149732 http://dx.doi.org/10.3389/fimmu.2021.690207 |
work_keys_str_mv | AT cuiyudan regulatoryeffectsofhistonedeacetylaseinhibitorsonmyeloidderivedsuppressorcells AT caijingshan regulatoryeffectsofhistonedeacetylaseinhibitorsonmyeloidderivedsuppressorcells AT wangwenxin regulatoryeffectsofhistonedeacetylaseinhibitorsonmyeloidderivedsuppressorcells AT wangshengjun regulatoryeffectsofhistonedeacetylaseinhibitorsonmyeloidderivedsuppressorcells |